Histone deacetylase 4, also known as HDAC4, is a human gene.

section_title =
summary_text = Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.cite web | title = Entrez Gene: HDAC4 histone deacetylase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9759| accessdate = ]

ee also

* Histone deacetylase


Further reading

citations =
*cite journal | author=Pazin MJ, Kadonaga JT |title=What's up and down with histone deacetylation and transcription? |journal=Cell |volume=89 |issue= 3 |pages= 325–8 |year= 1997 |pmid= 9150131 |doi=
*cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286–93 |year= 2003 |pmid= 12711221 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Wolffe AP |title=Transcriptional control. Sinful repression. |journal=Nature |volume=387 |issue= 6628 |pages= 16–7 |year= 1997 |pmid= 9139815 |doi= 10.1038/387016a0
*cite journal | author=Ohara O, Nagase T, Ishikawa K, "et al." |title=Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. |journal=DNA Res. |volume=4 |issue= 1 |pages= 53–9 |year= 1997 |pmid= 9179496 |doi=
*cite journal | author=Fischle W, Emiliani S, Hendzel MJ, "et al." |title=A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11713–20 |year= 1999 |pmid= 10206986 |doi=
*cite journal | author=Grozinger CM, Hassig CA, Schreiber SL |title=Three proteins define a class of human histone deacetylases related to yeast Hda1p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4868–73 |year= 1999 |pmid= 10220385 |doi=
*cite journal | author=Miska EA, Karlsson C, Langley E, "et al." |title=HDAC4 deacetylase associates with and represses the MEF2 transcription factor. |journal=EMBO J. |volume=18 |issue= 18 |pages= 5099–107 |year= 1999 |pmid= 10487761 |doi= 10.1093/emboj/18.18.5099
*cite journal | author=Wang AH, Bertos NR, Vezmar M, "et al." |title=HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7816–27 |year= 1999 |pmid= 10523670 |doi=
*cite journal | author=Youn HD, Grozinger CM, Liu JO |title=Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22563–7 |year= 2000 |pmid= 10825153 |doi= 10.1074/jbc.C000304200
*cite journal | author=Grozinger CM, Schreiber SL |title=Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7835–40 |year= 2000 |pmid= 10869435 |doi= 10.1073/pnas.140199597
*cite journal | author=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi=
*cite journal | author=Li J, Wang J, Wang J, "et al." |title=Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4342–50 |year= 2000 |pmid= 10944117 |doi= 10.1093/emboj/19.16.4342
*cite journal | author=Wang AH, Kruhlak MJ, Wu J, "et al." |title=Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6904–12 |year= 2000 |pmid= 10958686 |doi=
*cite journal | author=Zhang CL, McKinsey TA, Lu JR, Olson EN |title=Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 35–9 |year= 2001 |pmid= 11022042 |doi= 10.1074/jbc.M007364200
*cite journal | author=McKinsey TA, Zhang CL, Lu J, Olson EN |title=Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. |journal=Nature |volume=408 |issue= 6808 |pages= 106–11 |year= 2000 |pmid= 11081517 |doi= 10.1038/35040593
*cite journal | author=Zhou X, Richon VM, Wang AH, "et al." |title=Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14329–33 |year= 2001 |pmid= 11114188 |doi= 10.1073/pnas.250494697
*cite journal | author=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497

External links


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