PTPN7

Protein tyrosine phosphatase, non-receptor type 7, also known as PTPN7, is a human gene.cite web | title = Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5778| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5778| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Adachi M, Sekiya M, Arimura Y, "et al." |title=Protein-tyrosine phosphatase expression in pre-B cell NALM-6. |journal=Cancer Res. |volume=52 |issue= 3 |pages= 737–40 |year= 1992 |pmid= 1370651 |doi=
*cite journal | author=Adachi M, Sekiya M, Isobe M, "et al." |title=Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP. |journal=Biochem. Biophys. Res. Commun. |volume=186 |issue= 3 |pages= 1607–15 |year= 1992 |pmid= 1510684 |doi=
*cite journal | author=Zanke B, Suzuki H, Kishihara K, "et al." |title=Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase). |journal=Eur. J. Immunol. |volume=22 |issue= 1 |pages= 235–9 |year= 1992 |pmid= 1530918 |doi=
*cite journal | author=Swieter M, Berenstein EH, Swaim WD, Siraganian RP |title=Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21902–6 |year= 1995 |pmid= 7545170 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Zanke B, Squire J, Griesser H, "et al." |title=A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1. |journal=Leukemia |volume=8 |issue= 2 |pages= 236–44 |year= 1994 |pmid= 8309248 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Saxena M, Williams S, Gilman J, Mustelin T |title=Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP). |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15340–4 |year= 1998 |pmid= 9624114 |doi=
*cite journal | author=Saxena M, Williams S, Brockdorff J, "et al." |title=Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP). |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11693–700 |year= 1999 |pmid= 10206983 |doi=
*cite journal | author=Oh-hora M, Ogata M, Mori Y, "et al." |title=Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase. |journal=J. Immunol. |volume=163 |issue= 3 |pages= 1282–8 |year= 1999 |pmid= 10415025 |doi=
*cite journal | author=Saxena M, Williams S, Taskén K, Mustelin T |title=Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase. |journal=Nat. Cell Biol. |volume=1 |issue= 5 |pages= 305–11 |year= 1999 |pmid= 10559944 |doi= 10.1038/13024
*cite journal | author=Pettiford SM, Herbst R |title=The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP. |journal=Oncogene |volume=19 |issue= 7 |pages= 858–69 |year= 2000 |pmid= 10702794 |doi= 10.1038/sj.onc.1203408
*cite journal | author=Gjörloff-Wingren A, Saxena M, Han S, "et al." |title=Subcellular localization of intracellular protein tyrosine phosphatases in T cells. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2412–21 |year= 2000 |pmid= 10940933 |doi=
*cite journal | author=Tartaglia M, Mehler EL, Goldberg R, "et al." |title=Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. |journal=Nat. Genet. |volume=29 |issue= 4 |pages= 465–8 |year= 2001 |pmid= 11704759 |doi= 10.1038/ng772
*cite journal | author=Wang ZX, Zhou B, Wang QM, Zhang ZY |title=A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity. |journal=Biochemistry |volume=41 |issue= 24 |pages= 7849–57 |year= 2002 |pmid= 12056917 |doi=
*cite journal | author=Digilio MC, Conti E, Sarkozy A, "et al." |title=Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. |journal=Am. J. Hum. Genet. |volume=71 |issue= 2 |pages= 389–94 |year= 2002 |pmid= 12058348 |doi=
*cite journal | author=Kosaki K, Suzuki T, Muroya K, "et al." |title=PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 8 |pages= 3529–33 |year= 2002 |pmid= 12161469 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pettiford SM, Herbst R |title=The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells. |journal=Leukemia |volume=17 |issue= 2 |pages= 366–78 |year= 2003 |pmid= 12592337 |doi= 10.1038/sj.leu.2402767
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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