FASTK

FASTK

Fas-activated serine/threonine kinase, also known as FASTK, is a human gene.cite web | title = Entrez Gene: FASTK Fas-activated serine/threonine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10922| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.cite web | title = Entrez Gene: FASTK Fas-activated serine/threonine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10922| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tian Q, Taupin J, Elledge S, "et al." |title=Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. |journal=J. Exp. Med. |volume=182 |issue= 3 |pages= 865–74 |year= 1995 |pmid= 7544399 |doi=
*cite journal | author=Auffray C, Behar G, Bois F, "et al." |title= [

*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Li W, Kedersha N, Chen S, "et al." |title=FAST is a BCL-X(L)-associated mitochondrial protein. |journal=Biochem. Biophys. Res. Commun. |volume=318 |issue= 1 |pages= 95–102 |year= 2004 |pmid= 15110758 |doi= 10.1016/j.bbrc.2004.03.188
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li W, Simarro M, Kedersha N, Anderson P |title=FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10718–32 |year= 2004 |pmid= 15572676 |doi= 10.1128/MCB.24.24.10718-10732.2004
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Izquierdo JM, Valcárcel J |title=Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1539–43 |year= 2007 |pmid= 17135269 |doi= 10.1074/jbc.C600198200
*cite journal | author=Simarro M, Mauger D, Rhee K, "et al." |title=Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 27 |pages= 11370–5 |year= 2007 |pmid= 17592127 |doi= 10.1073/pnas.0704964104

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