MARK2

MAP/microtubule affinity-regulating kinase 2, also known as MARK2, is a human gene.cite web | title = Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011| accessdate = ]

PBB_Summary
section_title =
summary_text = EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.cite web | title = Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Courseaux A, Fernandes M, Grosgeorge J, "et al." |title=Human EMK1 is located on 11q12-q13, close to COX8 and FTH1. |journal=Mamm. Genome |volume=6 |issue= 4 |pages= 311–2 |year= 1995 |pmid= 7613050 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Courseaux A, Grosgeorge J, Gaudray P, "et al." |title=Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). |journal=Genomics |volume=37 |issue= 3 |pages= 354–65 |year= 1997 |pmid= 8938448 |doi=
*cite journal | author=Drewes G, Ebneth A, Preuss U, "et al." |title=MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. |journal=Cell |volume=89 |issue= 2 |pages= 297–308 |year= 1997 |pmid= 9108484 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Espinosa L, Navarro E |title=Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 278–82 |year= 1998 |pmid= 9730619 |doi=
*cite journal | author=Navarro E |title=Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 1 |pages= 66–7 |year= 1999 |pmid= 10516437 |doi=
*cite journal | author=Sun TQ, Lu B, Feng JJ, "et al." |title=PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. |journal=Nat. Cell Biol. |volume=3 |issue= 7 |pages= 628–36 |year= 2001 |pmid= 11433294 |doi= 10.1038/35083016
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brajenovic M, Joberty G, Küster B, "et al." |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804–11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Lizcano JM, Göransson O, Toth R, "et al." |title=LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. |journal=EMBO J. |volume=23 |issue= 4 |pages= 833–43 |year= 2005 |pmid= 14976552 |doi= 10.1038/sj.emboj.7600110
*cite journal | author=Hueso M, Beltran V, Moreso F, "et al." |title=Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients. |journal=Biochim. Biophys. Acta |volume=1689 |issue= 1 |pages= 58–65 |year= 2004 |pmid= 15158914 |doi= 10.1016/j.bbadis.2004.01.008
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Suzuki A, Hirata M, Kamimura K, "et al." |title=aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1425–35 |year= 2004 |pmid= 15324659 |doi= 10.1016/j.cub.2004.08.021
*cite journal | author=Cohen D, Rodriguez-Boulan E, Müsch A |title=Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 38 |pages= 13792–7 |year= 2004 |pmid= 15365179 |doi= 10.1073/pnas.0403684101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hazarika P, McCarty MF, Prieto VG, "et al." |title=Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. |journal=Cancer Res. |volume=64 |issue= 20 |pages= 7361–9 |year= 2004 |pmid= 15492257 |doi= 10.1158/0008-5472.CAN-04-0823

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