MAPKAPK3

Mitogen-activated protein kinase-activated protein kinase 3, also known as MAPKAPK3, is a human gene.cite web | title = Entrez Gene: MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7867| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.cite web | title = Entrez Gene: MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7867| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wei MH, Latif F, Bader S, "et al." |title=Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1487–92 |year= 1996 |pmid= 8603390 |doi=
*cite journal | author=Sithanandam G, Latif F, Duh FM, "et al." |title=3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 868–76 |year= 1996 |pmid= 8622688 |doi=
*cite journal | author=McLaughlin MM, Kumar S, McDonnell PC, "et al." |title=Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8488–92 |year= 1996 |pmid= 8626550 |doi=
*cite journal | author=Clifton AD, Young PR, Cohen P |title=A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. |journal=FEBS Lett. |volume=392 |issue= 3 |pages= 209–14 |year= 1996 |pmid= 8774846 |doi=
*cite journal | author=Ludwig S, Engel K, Hoffmeyer A, "et al." |title=3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6687–97 |year= 1997 |pmid= 8943323 |doi=
*cite journal | author=Kumar S, McDonnell PC, Gum RJ, "et al." |title=Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 533–8 |year= 1997 |pmid= 9207191 |doi= 10.1006/bbrc.1997.6849
*cite journal | author=Neufeld B, Grosse-Wilde A, Hoffmeyer A, "et al." |title=Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20239–42 |year= 2000 |pmid= 10781029 |doi= 10.1074/jbc.C901040199
*cite journal | author=Tanoue T, Maeda R, Adachi M, Nishida E |title=Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. |journal=EMBO J. |volume=20 |issue= 3 |pages= 466–79 |year= 2001 |pmid= 11157753 |doi= 10.1093/emboj/20.3.466
*cite journal | author=Simkhovich BZ, Abdishoo S, Poizat C, "et al." |title=Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study. |journal=Heart disease (Hagerstown, Md.) |volume=4 |issue= 2 |pages= 63–9 |year= 2002 |pmid= 11975836 |doi=
*cite journal | author=Knebel A, Haydon CE, Morrice N, Cohen P |title=Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 525–32 |year= 2002 |pmid= 12171600 |doi= 10.1042/BJ20020916
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zakowski V, Keramas G, Kilian K, "et al." |title=Mitogen-activated 3p kinase is active in the nucleus. |journal=Exp. Cell Res. |volume=299 |issue= 1 |pages= 101–9 |year= 2004 |pmid= 15302577 |doi= 10.1016/j.yexcr.2004.05.027
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Voncken JW, Niessen H, Neufeld B, "et al." |title=MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5178–87 |year= 2005 |pmid= 15563468 |doi= 10.1074/jbc.M407155200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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