TANK-binding kinase 1

TANK-binding kinase 1, also known as TBK1, is a human gene.cite web | title = Entrez Gene: TBK1 TANK-binding kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29110| accessdate = ]

PBB_Summary
section_title =
summary_text = The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.cite web | title = Entrez Gene: TBK1 TANK-binding kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29110| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chou MM, Hanafusa H |title=A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7359–64 |year= 1995 |pmid= 7706279 |doi=
*cite journal | author=Chen ZJ, Parent L, Maniatis T |title=Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. |journal=Cell |volume=84 |issue= 6 |pages= 853–62 |year= 1996 |pmid= 8601309 |doi=
*cite journal | author=Zandi E, Chen Y, Karin M |title=Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. |journal=Science |volume=281 |issue= 5381 |pages= 1360–3 |year= 1998 |pmid= 9721103 |doi=
*cite journal | author=Pomerantz JL, Baltimore D |title=NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. |journal=EMBO J. |volume=18 |issue= 23 |pages= 6694–704 |year= 2000 |pmid= 10581243 |doi= 10.1093/emboj/18.23.6694
*cite journal | author=Tojima Y, Fujimoto A, Delhase M, "et al." |title=NAK is an IkappaB kinase-activating kinase. |journal=Nature |volume=404 |issue= 6779 |pages= 778–82 |year= 2000 |pmid= 10783893 |doi= 10.1038/35008109
*cite journal | author=Bonnard M, Mirtsos C, Suzuki S, "et al." |title=Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. |journal=EMBO J. |volume=19 |issue= 18 |pages= 4976–85 |year= 2000 |pmid= 10990461 |doi= 10.1093/emboj/19.18.4976
*cite journal | author=Kishore N, Huynh QK, Mathialagan S, "et al." |title=IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13840–7 |year= 2002 |pmid= 11839743 |doi= 10.1074/jbc.M110474200
*cite journal | author=Chariot A, Leonardi A, Muller J, "et al." |title=Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37029–36 |year= 2002 |pmid= 12133833 |doi= 10.1074/jbc.M205069200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li SF, Fujita F, Hirai M, "et al." |title=Genomic structure and characterization of the promoter region of the human NAK gene. |journal=Gene |volume=304 |issue= |pages= 57–64 |year= 2003 |pmid= 12568715 |doi=
*cite journal | author=Fitzgerald KA, McWhirter SM, Faia KL, "et al." |title=IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. |journal=Nat. Immunol. |volume=4 |issue= 5 |pages= 491–6 |year= 2003 |pmid= 12692549 |doi= 10.1038/ni921
*cite journal | author=Sharma S, tenOever BR, Grandvaux N, "et al." |title=Triggering the interferon antiviral response through an IKK-related pathway. |journal=Science |volume=300 |issue= 5622 |pages= 1148–51 |year= 2003 |pmid= 12702806 |doi= 10.1126/science.1081315
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Sato S, Sugiyama M, Yamamoto M, "et al." |title=Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. |journal=J. Immunol. |volume=171 |issue= 8 |pages= 4304–10 |year= 2004 |pmid= 14530355 |doi=
*cite journal | author=Fujita F, Taniguchi Y, Kato T, "et al." |title=Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7780–93 |year= 2003 |pmid= 14560022 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=tenOever BR, Sharma S, Zou W, "et al." |title=Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. |journal=J. Virol. |volume=78 |issue= 19 |pages= 10636–49 |year= 2004 |pmid= 15367631 |doi= 10.1128/JVI.78.19.10636-10649.2004
*cite journal | author=Kuai J, Wooters J, Hall JP, "et al." |title=NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53266–71 |year= 2005 |pmid= 15485837 |doi= 10.1074/jbc.M411037200
*cite journal | author=Buss H, Dörrie A, Schmitz ML, "et al." |title=Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55633-43 |year= 2005 |pmid= 15489227 |doi= 10.1074/jbc.M409825200

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