- TANK (gene)
TRAF family member-associated NFKB activator, also known as TANK, is a human
gene .cite web | title = Entrez Gene: TANK TRAF family member-associated NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10010| accessdate = ]PBB_Summary
section_title =
summary_text = The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: TANK TRAF family member-associated NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10010| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Rothe M, Xiong J, Shu HB, "et al." |title=I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8241–6 |year= 1996 |pmid= 8710854 |doi=
*cite journal | author=Kaye KM, Devergne O, Harada JN, "et al." |title=Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 11085–90 |year= 1996 |pmid= 8855313 |doi=
*cite journal | author=Chin AI, Shu J, Shan Shi C, "et al." |title=TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6665–72 |year= 2000 |pmid= 10490605 |doi=
*cite journal | author=Pomerantz JL, Baltimore D |title=NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. |journal=EMBO J. |volume=18 |issue= 23 |pages= 6694–704 |year= 2000 |pmid= 10581243 |doi= 10.1093/emboj/18.23.6694
*cite journal | author=Nomura F, Kawai T, Nakanishi K, Akira S |title=NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. |journal=Genes Cells |volume=5 |issue= 3 |pages= 191–202 |year= 2000 |pmid= 10759890 |doi=
*cite journal | author=Zapata JM, Pawlowski K, Haas E, "et al." |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200
*cite journal | author=Li C, Ni CZ, Havert ML, "et al." |title=Downstream regulator TANK binds to the CD40 recognition site on TRAF3. |journal=Structure |volume=10 |issue= 3 |pages= 403–11 |year= 2002 |pmid= 12005438 |doi=
*cite journal | author=Chariot A, Leonardi A, Muller J, "et al." |title=Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37029–36 |year= 2002 |pmid= 12133833 |doi= 10.1074/jbc.M205069200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ishida R, Ezura Y, Emi M, "et al." |title=Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women. |journal=Bone |volume=33 |issue= 2 |pages= 237–41 |year= 2004 |pmid= 14499357 |doi=
*cite journal | author=Li C, Norris PS, Ni CZ, "et al." |title=Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50523–9 |year= 2004 |pmid= 14517219 |doi= 10.1074/jbc.M309381200
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Bonif M, Meuwis MA, Close P, "et al." |title=TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. |journal=Biochem. J. |volume=394 |issue= Pt 3 |pages= 593–603 |year= 2006 |pmid= 16336209 |doi= 10.1042/BJ20051659
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Guo B, Cheng G |title=Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 11817–26 |year= 2007 |pmid= 17327220 |doi= 10.1074/jbc.M700017200
*cite journal | author=Ryzhakov G, Randow F |title=SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. |journal=EMBO J. |volume=26 |issue= 13 |pages= 3180–90 |year= 2007 |pmid= 17568778 |doi= 10.1038/sj.emboj.7601743
*cite journal | author=Gatot JS, Gioia R, Chau TL, "et al." |title=Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. |journal=J. Biol. Chem. |volume=282 |issue= 43 |pages= 31131–46 |year= 2007 |pmid= 17823124 |doi= 10.1074/jbc.M701690200PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
Wikimedia Foundation. 2010.
