- LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila), also known as LATS2, is a human
gene .cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.cite web | title = Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Yabuta N, Fujii T, Copeland NG, "et al." |title=Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. |journal=Genomics |volume=63 |issue= 2 |pages= 263–70 |year= 2000 |pmid= 10673337 |doi= 10.1006/geno.1999.6065
*cite journal | author=Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T |title=Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. |journal=Oncogene |volume=19 |issue= 27 |pages= 3101–9 |year= 2000 |pmid= 10871863 |doi= 10.1038/sj.onc.1203659
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li Y, Pei J, Xia H, "et al." |title=Lats2, a putative tumor suppressor, inhibits G1/S transition. |journal=Oncogene |volume=22 |issue= 28 |pages= 4398–405 |year= 2003 |pmid= 12853976 |doi= 10.1038/sj.onc.1206603
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Powzaniuk M, McElwee-Witmer S, Vogel RL, "et al." |title=The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2011–23 |year= 2005 |pmid= 15131260 |doi= 10.1210/me.2004-0065
*cite journal | author=Toji S, Yabuta N, Hosomi T, "et al." |title=The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. |journal=Genes Cells |volume=9 |issue= 5 |pages= 383–97 |year= 2005 |pmid= 15147269 |doi= 10.1111/j.1356-9597.2004.00732.x
*cite journal | author=Ke H, Pei J, Ni Z, "et al." |title=Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). |journal=Exp. Cell Res. |volume=298 |issue= 2 |pages= 329–38 |year= 2004 |pmid= 15265683 |doi= 10.1016/j.yexcr.2004.04.031
*cite journal | author=Chan EH, Nousiainen M, Chalamalasetty RB, "et al." |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445
*cite journal | author=Takahashi Y, Miyoshi Y, Takahata C, "et al." |title=Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. |journal=Clin. Cancer Res. |volume=11 |issue= 4 |pages= 1380–5 |year= 2005 |pmid= 15746036 |doi= 10.1158/1078-0432.CCR-04-1773
*cite journal | author=Abe Y, Ohsugi M, Haraguchi K, "et al." |title=LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. |journal=FEBS Lett. |volume=580 |issue= 3 |pages= 782–8 |year= 2006 |pmid= 16413547 |doi= 10.1016/j.febslet.2005.12.096
*cite journal | author=Voorhoeve PM, le Sage C, Schrier M, "et al." |title=A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. |journal=Cell |volume=124 |issue= 6 |pages= 1169–81 |year= 2006 |pmid= 16564011 |doi= 10.1016/j.cell.2006.02.037
*cite journal | author=Aylon Y, Michael D, Shmueli A, "et al." |title=A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. |journal=Genes Dev. |volume=20 |issue= 19 |pages= 2687–700 |year= 2007 |pmid= 17015431 |doi= 10.1101/gad.1447006
*cite journal | author=Jiang Z, Li X, Hu J, "et al." |title=Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. |journal=Neurosci. Res. |volume=56 |issue= 4 |pages= 450–8 |year= 2007 |pmid= 17049657 |doi= 10.1016/j.neures.2006.09.006PBB_Controls
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