PRKCQ

Protein kinase C, theta, also known as PRKCQ, is a human gene.

PBB_Summary
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summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [cite web | title = Entrez Gene: PRKCQ protein kinase C, theta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5588| accessdate = ]

ee also

*Protein kinase C

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Meller N, Altman A, Isakov N |title=New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C. |journal=Stem Cells |volume=16 |issue= 3 |pages= 178–92 |year= 1998 |pmid= 9617893 |doi=
*cite journal | author=Greenway AL, Holloway G, McPhee DA, "et al." |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 12734410 |doi=
*cite journal | author=Ruegg CL, Strand M |title=A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. |journal=Cell. Immunol. |volume=137 |issue= 1 |pages= 1–13 |year= 1991 |pmid= 1832084 |doi=
*cite journal | author=Chowdhury IH, Koyanagi Y, Kobayashi S, "et al." |title=The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway. |journal=Virology |volume=176 |issue= 1 |pages= 126–32 |year= 1990 |pmid= 1970444 |doi=
*cite journal | author=Ruegg CL, Strand M |title=Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41. |journal=J. Immunol. |volume=144 |issue= 10 |pages= 3928–35 |year= 1990 |pmid= 2139676 |doi=
*cite journal | author=Jakobovits A, Rosenthal A, Capon DJ |title=Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C. |journal=EMBO J. |volume=9 |issue= 4 |pages= 1165–70 |year= 1990 |pmid= 2182321 |doi=
*cite journal | author=Fields AP, Bednarik DP, Hess A, May WS |title=Human immunodeficiency virus induces phosphorylation of its cell surface receptor. |journal=Nature |volume=333 |issue= 6170 |pages= 278–80 |year= 1988 |pmid= 3259291 |doi= 10.1038/333278a0
*cite journal | author=Chirmule N, Goonewardena H, Pahwa S, "et al." |title=HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19364–9 |year= 1995 |pmid= 7642615 |doi=
*cite journal | author=Chang JD, Xu Y, Raychowdhury MK, Ware JA |title=Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. |journal=J. Biol. Chem. |volume=268 |issue= 19 |pages= 14208–14 |year= 1993 |pmid= 7686153 |doi=
*cite journal | author=Erdel M, Baier-Bitterlich G, Duba C, "et al." |title=Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH. |journal=Genomics |volume=25 |issue= 2 |pages= 595–7 |year= 1995 |pmid= 7790001 |doi=
*cite journal | author=Ward NE, Gravitt KR, O'Brian CA |title=Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein. |journal=Cancer Lett. |volume=88 |issue= 1 |pages= 37–40 |year= 1995 |pmid= 7850771 |doi=
*cite journal | author=Gupta S, Aggarwal S, Kim C, Gollapudi S |title=Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report. |journal=Int. J. Immunopharmacol. |volume=16 |issue= 3 |pages= 197–204 |year= 1994 |pmid= 8206685 |doi=
*cite journal | author=Baier G, Telford D, Giampa L, "et al." |title=Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. |journal=J. Biol. Chem. |volume=268 |issue= 7 |pages= 4997–5004 |year= 1993 |pmid= 8444877 |doi=
*cite journal | author=Parada NA, Cruikshank WW, Danis HL, "et al." |title=IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. |journal=Cell. Immunol. |volume=168 |issue= 1 |pages= 100–6 |year= 1996 |pmid= 8599832 |doi= 10.1006/cimm.1996.0054
*cite journal | author=Conant K, Ma M, Nath A, Major EO |title=Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. |journal=J. Virol. |volume=70 |issue= 3 |pages= 1384–9 |year= 1996 |pmid= 8627654 |doi=
*cite journal | author=Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P |title=The HIV nef protein associates with protein kinase C theta. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16753–7 |year= 1996 |pmid= 8663223 |doi=
*cite journal | author=Meller N, Liu YC, Collins TL, "et al." |title=Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5782–91 |year= 1996 |pmid= 8816492 |doi=
*cite journal | author=Holmes AM |title=In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46. |journal=Arch. Biochem. Biophys. |volume=335 |issue= 1 |pages= 8–12 |year= 1996 |pmid= 8914829 |doi= 10.1006/abbi.1996.0476
*cite journal | author=Monks CR, Kupfer H, Tamir I, "et al." |title=Selective modulation of protein kinase C-theta during T-cell activation. |journal=Nature |volume=385 |issue= 6611 |pages= 83–6 |year= 1997 |pmid= 8985252 |doi= 10.1038/385083a0
*cite journal | author=Datta R, Kojima H, Yoshida K, Kufe D |title=Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20317–20 |year= 1997 |pmid= 9252332 |doi=

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