- MAP3K14
Mitogen-activated protein kinase kinase kinase 14, also known as MAP3K14, is a human
gene .cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Malinin NL, Boldin MP, Kovalenko AV, Wallach D |title=MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. |journal=Nature |volume=385 |issue= 6616 |pages= 540–4 |year= 1997 |pmid= 9020361 |doi= 10.1038/385540a0
*cite journal | author=Régnier CH, Song HY, Gao X, "et al." |title=Identification and characterization of an IkappaB kinase. |journal=Cell |volume=90 |issue= 2 |pages= 373–83 |year= 1997 |pmid= 9244310 |doi=
*cite journal | author=Song HY, Régnier CH, Kirschning CJ, "et al." |title=Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9792–6 |year= 1997 |pmid= 9275204 |doi=
*cite journal | author=Woronicz JD, Gao X, Cao Z, "et al." |title=IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. |journal=Science |volume=278 |issue= 5339 |pages= 866–9 |year= 1997 |pmid= 9346485 |doi=
*cite journal | author=Ling L, Cao Z, Goeddel DV |title=NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3792–7 |year= 1998 |pmid= 9520446 |doi=
*cite journal | author=Lee FS, Peters RT, Dang LC, Maniatis T |title=MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9319–24 |year= 1998 |pmid= 9689078 |doi=
*cite journal | author=Lin X, Mu Y, Cunningham ET, "et al." |title=Molecular determinants of NF-kappaB-inducing kinase action. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5899–907 |year= 1998 |pmid= 9742107 |doi=
*cite journal | author=Cohen L, Henzel WJ, Baeuerle PA |title=IKAP is a scaffold protein of the IkappaB kinase complex. |journal=Nature |volume=395 |issue= 6699 |pages= 292–6 |year= 1998 |pmid= 9751059 |doi= 10.1038/26254
*cite journal | author=Aronsson FC, Magnusson P, Andersson B, "et al." |title=The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. |journal=Hum. Genet. |volume=103 |issue= 3 |pages= 340–5 |year= 1998 |pmid= 9799091 |doi=
*cite journal | author=Nemoto S, DiDonato JA, Lin A |title=Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7336–43 |year= 1998 |pmid= 9819420 |doi=
*cite journal | author=Li Y, Kang J, Friedman J, "et al." |title=Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 3 |pages= 1042–7 |year= 1999 |pmid= 9927690 |doi=
*cite journal | author=Lallena MJ, Diaz-Meco MT, Bren G, "et al." |title=Activation of IkappaB kinase beta by protein kinase C isoforms. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2180–8 |year= 1999 |pmid= 10022904 |doi=
*cite journal | author=Lin X, Cunningham ET, Mu Y, "et al." |title=The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. |journal=Immunity |volume=10 |issue= 2 |pages= 271–80 |year= 1999 |pmid= 10072079 |doi=
*cite journal | author=Ninomiya-Tsuji J, Kishimoto K, Hiyama A, "et al." |title=The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. |journal=Nature |volume=398 |issue= 6724 |pages= 252–6 |year= 1999 |pmid= 10094049 |doi= 10.1038/18465
*cite journal | author=Delhase M, Hayakawa M, Chen Y, Karin M |title=Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. |journal=Science |volume=284 |issue= 5412 |pages= 309–13 |year= 1999 |pmid= 10195894 |doi=
*cite journal | author=Hu WH, Johnson H, Shu HB |title=Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30603–10 |year= 1999 |pmid= 10521444 |doi=
*cite journal | author=Yamamoto Y, Yin MJ, Gaynor RB |title=IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3655–66 |year= 2000 |pmid= 10779355 |doi=
*cite journal | author=Xiao G, Sun SC |title=Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21081–5 |year= 2000 |pmid= 10887201 |doi= 10.1074/jbc.M002552200
*cite journal | author=Chaudhary PM, Eby MT, Jasmin A, "et al." |title=Activation of the NF-kappaB pathway by caspase 8 and its homologs. |journal=Oncogene |volume=19 |issue= 39 |pages= 4451–60 |year= 2000 |pmid= 11002417 |doi= 10.1038/sj.onc.1203812
*cite journal | author=Kumar A, Eby MT, Sinha S, "et al." |title=The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2668–77 |year= 2001 |pmid= 11035039 |doi= 10.1074/jbc.M008356200PBB_Controls
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