STUB1

STUB1

STUB1 (STIP1 homology and U-Box containing protein 1), also known as CHIP (C terminus of HSC70-Interacting Protein), is a human gene.cite web | title = Entrez Gene: STUB1 STIP1 homology and U-box containing protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10273| accessdate = ] cite journal | author = Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C | title = Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4535–45 | year = 1999 | month = June | pmid = 10330192 | pmc = 104411 | url = http://mcb.asm.org/cgi/content/abstract/19/6/4535 | issn = ]

Function

The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation.cite journal | author = Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Höhfeld J, Patterson C | title = CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 42938–44 | year = 2001 | month = November | pmid = 11557750 | doi = 10.1074/jbc.M101968200 | url = | issn = ] CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery.cite journal | author = Qian SB, McDonough H, Boellmann F, Cyr DM, Patterson C | title = CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 | journal = Nature | volume = 440 | issue = 7083 | pages = 551–5 | year = 2006 | month = March | pmid = 16554822 | doi = 10.1038/nature04600 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Patterson C |title=A new gun in town: the U box is a ubiquitin ligase domain. |journal=Sci. STKE |volume=2002 |issue= 116 |pages= PE4 |year= 2002 |pmid= 11805346 |doi= 10.1126/stke.2002.116.pe4
*cite journal | author=Scanlan MJ, Chen YT, Williamson B, "et al." |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652–8 |year= 1998 |pmid= 9610721 |doi=
*cite journal | author=Ballinger CA, Connell P, Wu Y, "et al." |title=Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4535–45 |year= 1999 |pmid= 10330192 |doi=
*cite journal | author=Connell P, Ballinger CA, Jiang J, "et al." |title=The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 93–6 |year= 2001 |pmid= 11146632 |doi= 10.1038/35050618
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Jiang J, Ballinger CA, Wu Y, "et al." |title=CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 42938–44 |year= 2001 |pmid= 11557750 |doi= 10.1074/jbc.M101968200
*cite journal | author=Demand J, Alberti S, Patterson C, Höhfeld J |title=Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. |journal=Curr. Biol. |volume=11 |issue= 20 |pages= 1569–77 |year= 2002 |pmid= 11676916 |doi=
*cite journal | author=Imai Y, Soda M, Hatakeyama S, "et al." |title=CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. |journal=Mol. Cell |volume=10 |issue= 1 |pages= 55–67 |year= 2002 |pmid= 12150907 |doi=
*cite journal | author=Krackhardt AM, Witzens M, Harig S, "et al." |title=Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. |journal=Blood |volume=100 |issue= 6 |pages= 2123–31 |year= 2002 |pmid= 12200376 |doi= 10.1182/blood-2002-02-0513
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cardozo CP, Michaud C, Ost MC, "et al." |title=C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. |journal=Arch. Biochem. Biophys. |volume=410 |issue= 1 |pages= 134–40 |year= 2003 |pmid= 12559985 |doi=
*cite journal | author=Zhou P, Fernandes N, Dodge IL, "et al." |title=ErbB2 degradation mediated by the co-chaperone protein CHIP. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13829–37 |year= 2003 |pmid= 12574167 |doi= 10.1074/jbc.M209640200
*cite journal | author=Shimura H, Schwartz D, Gygi SP, Kosik KS |title=CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4869–76 |year= 2004 |pmid= 14612456 |doi= 10.1074/jbc.M305838200
*cite journal | author=Li L, Xin H, Xu X, "et al." |title=CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 856–64 |year= 2004 |pmid= 14701756 |doi=
*cite journal | author=Petrucelli L, Dickson D, Kehoe K, "et al." |title=CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. |journal=Hum. Mol. Genet. |volume=13 |issue= 7 |pages= 703–14 |year= 2004 |pmid= 14962978 |doi= 10.1093/hmg/ddh083
*cite journal | author=Galigniana MD, Harrell JM, Housley PR, "et al." |title=Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. |journal=Brain Res. Mol. Brain Res. |volume=123 |issue= 1-2 |pages= 27–36 |year= 2004 |pmid= 15046863 |doi= 10.1016/j.molbrainres.2003.12.015
*cite journal | author=He B, Bai S, Hnat AT, "et al." |title=An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP). |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30643–53 |year= 2004 |pmid= 15107424 |doi= 10.1074/jbc.M403117200
*cite journal | author=Alberti S, Böhse K, Arndt V, "et al." |title=The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. |journal=Mol. Biol. Cell |volume=15 |issue= 9 |pages= 4003–10 |year= 2005 |pmid= 15215316 |doi= 10.1091/mbc.E04-04-0293
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • stub — stub1 stubber, n. /stub/, n., v., stubbed, stubbing. n. 1. a short projecting part. 2. a short remaining piece, as of a pencil, candle, or cigar. 3. (in a checkbook, receipt book, etc.) the inner end of each leaf, for keeping a record of the… …   Universalium

  • stub — stub1 [stʌb] n [: Old English; Origin: stybb] 1.) the short part of something long and thin, such as a cigarette or pencil, that is left when the rest has been used ▪ a pencil stub 2.) the part of a ticket that is given back to you after it has… …   Dictionary of contemporary English

  • stub — stub1 [ stʌb ] verb transitive to hit your toe against something accidentally in a hard and painful way ,stub out phrasal verb transitive to press a cigarette hard against a surface to make it stop burning stub stub 2 [ stʌb ] noun count 1. ) the …   Usage of the words and phrases in modern English

  • Parkin (ligase) — For other uses, see Parkin (disambiguation). Parkinson protein 2, E3 ubiquitin protein ligase (parkin) PDB rendering based on 1iyf …   Wikipedia

  • DNAJB1 — DnaJ (Hsp40) homolog, subfamily B, member 1 PDB rendering based on 1hdj …   Wikipedia

  • stab — /stab/, v., stabbed, stabbing, n. v.t. 1. to pierce or wound with or as if with a pointed weapon: She stabbed a piece of chicken with her fork. 2. to thrust, plunge, or jab (a knife, pointed weapon, or the like) into something: He stabbed the… …   Universalium

  • stob — /stob/, n. Chiefly South Midland U.S. a post, stump, or stake. [1275 1325; ME; var. of STUB1] * * * …   Universalium

  • stubbed — stubbedness, n. /stub id, stubd/, adj. 1. reduced to or resembling a stub; short and thick; stumpy. 2. abounding in or rough with stubs. [1520 30; STUB1 + ED3] * * * …   Universalium

  • stubby — stubbily, adv. stubbiness, n. /stub ee/, adj., stubbier, stubbiest. 1. of the nature of or resembling a stub. 2. short and thick or broad; thick set or squat: stubby fingers. 3. consisting of or abounding in stubs. 4. bristly, as the hair or… …   Universalium

  • HSPA4 — Proteína de choque térmico 4 HUGO 5237 Símbolo HSPA4 Símbolos alt. APG 2; HS24/P52; MGC131852; RY; hsp70; hsp70RY …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”