MAPK10

Mitogen-activated protein kinase 10, also known as MAPK10, is a human gene.cite web | title = Entrez Gene: MAPK10 mitogen-activated protein kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5602| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: MAPK10 mitogen-activated protein kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5602| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Freedman BD, Liu QH, Del Corno M, Collman RG |title=HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages. |journal=Immunol. Res. |volume=27 |issue= 2-3 |pages= 261–76 |year= 2004 |pmid= 12857973 |doi=
*cite journal | author=Lee C, Liu QH, Tomkowicz B, "et al." |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206
*cite journal | author=Pulverer BJ, Kyriakis JM, Avruch J, "et al." |title=Phosphorylation of c-jun mediated by MAP kinases. |journal=Nature |volume=353 |issue= 6345 |pages= 670–4 |year= 1991 |pmid= 1922387 |doi= 10.1038/353670a0
*cite journal | author=Mohit AA, Martin JH, Miller CA |title=p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. |journal=Neuron |volume=14 |issue= 1 |pages= 67–78 |year= 1995 |pmid= 7826642 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Gupta S, Barrett T, Whitmarsh AJ, "et al." |title=Selective interaction of JNK protein kinase isoforms with transcription factors. |journal=EMBO J. |volume=15 |issue= 11 |pages= 2760–70 |year= 1996 |pmid= 8654373 |doi=
*cite journal | author=Jabado N, Pallier A, Jauliac S, "et al." |title=gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes. |journal=Eur. J. Immunol. |volume=27 |issue= 2 |pages= 397–404 |year= 1997 |pmid= 9045910 |doi=
*cite journal | author=Yang DD, Kuan CY, Whitmarsh AJ, "et al." |title=Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. |journal=Nature |volume=389 |issue= 6653 |pages= 865–70 |year= 1997 |pmid= 9349820 |doi= 10.1038/39899
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hu MC, Qiu WR, Wang YP |title=JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. |journal=Oncogene |volume=15 |issue= 19 |pages= 2277–87 |year= 1997 |pmid= 9393873 |doi= 10.1038/sj.onc.1201401
*cite journal | author=Lannuzel A, Barnier JV, Hery C, "et al." |title=Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons. |journal=Ann. Neurol. |volume=42 |issue= 6 |pages= 847–56 |year= 1998 |pmid= 9403476 |doi= 10.1002/ana.410420605
*cite journal | author=Xie X, Gu Y, Fox T, "et al." |title=Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. |journal=Structure |volume=6 |issue= 8 |pages= 983–91 |year= 1998 |pmid= 9739089 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Koyano S, Ito M, Takamatsu N, "et al." |title=A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. |journal=FEBS Lett. |volume=457 |issue= 3 |pages= 385–8 |year= 1999 |pmid= 10471813 |doi=
*cite journal | author=Ito M, Yoshioka K, Akechi M, "et al." |title=JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7539–48 |year= 1999 |pmid= 10523642 |doi=
*cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=
*cite journal | author=Lisnock J, Griffin P, Calaycay J, "et al." |title=Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1. |journal=Biochemistry |volume=39 |issue= 11 |pages= 3141–8 |year= 2000 |pmid= 10715136 |doi=
*cite journal | author=McDonald PH, Chow CW, Miller WE, "et al." |title=Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. |journal=Science |volume=290 |issue= 5496 |pages= 1574–7 |year= 2000 |pmid= 11090355 |doi=
*cite journal | author=Pouysségur J |title=Signal transduction. An arresting start for MAPK. |journal=Science |volume=290 |issue= 5496 |pages= 1515–8 |year= 2000 |pmid= 11185509 |doi=
*cite journal | author=Habelhah H, Shah K, Huang L, "et al." |title=ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. |journal=Nat. Cell Biol. |volume=3 |issue= 3 |pages= 325–30 |year= 2001 |pmid= 11231586 |doi= 10.1038/35060131

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