MAP3K10

MAP3K10

Mitogen-activated protein kinase kinase kinase 10, also known as MAP3K10, is a human gene.cite web | title = Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.cite web | title = Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Katoh M, Hirai M, Sugimura T, Terada M |title=Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. |journal=Oncogene |volume=10 |issue= 7 |pages= 1447–51 |year= 1995 |pmid= 7731697 |doi=
*cite journal | author=Gallo KA, Mark MR, Scadden DT, "et al." |title=Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. |journal=J. Biol. Chem. |volume=269 |issue= 21 |pages= 15092–100 |year= 1994 |pmid= 8195146 |doi=
*cite journal | author=Dorow DS, Devereux L, Dietzsch E, De Kretser T |title=Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 701–10 |year= 1993 |pmid= 8477742 |doi=
*cite journal | author=Dorow DS, Devereux L, Tu GF, "et al." |title=Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. |journal=Eur. J. Biochem. |volume=234 |issue= 2 |pages= 492–500 |year= 1996 |pmid= 8536694 |doi=
*cite journal | author=Hirai S, Katoh M, Terada M, "et al." |title=MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15167–73 |year= 1997 |pmid= 9182538 |doi=
*cite journal | author=Nagata K, Puls A, Futter C, "et al." |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149–58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149
*cite journal | author=Hirai S, Noda K, Moriguchi T, "et al." |title=Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7406–12 |year= 1998 |pmid= 9516438 |doi=
*cite journal | author=Rasmussen RK, Ji H, Eddes JS, "et al." |title=Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins. |journal=Electrophoresis |volume=19 |issue= 5 |pages= 809–17 |year= 1998 |pmid= 9629920 |doi= 10.1002/elps.1150190535
*cite journal | author=Rasmussen RK, Rusak J, Price G, "et al." |title=Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid. |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 119–24 |year= 1998 |pmid= 9742220 |doi=
*cite journal | author=Liu YF, Dorow D, Marshall J |title=Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19035–40 |year= 2000 |pmid= 10801775 |doi= 10.1074/jbc.C000180200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Savinainen A, Garcia EP, Dorow D, "et al." |title=Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. |journal=J. Biol. Chem. |volume=276 |issue= 14 |pages= 11382–6 |year= 2001 |pmid= 11152698 |doi= 10.1074/jbc.M100190200
*cite journal | author=Xu Z, Maroney AC, Dobrzanski P, "et al." |title=The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4713–24 |year= 2001 |pmid= 11416147 |doi= 10.1128/MCB.21.14.4713-4724.2001
*cite journal | author=Poy MN, Yang Y, Rezaei K, "et al." |title=CEACAM1 regulates insulin clearance in liver. |journal=Nat. Genet. |volume=30 |issue= 3 |pages= 270–6 |year= 2002 |pmid= 11850617 |doi= 10.1038/ng840
*cite journal | author=Akbarzadeh S, Ji H, Frecklington D, "et al." |title=Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36280–7 |year= 2002 |pmid= 12105200 |doi= 10.1074/jbc.M204626200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Figueroa C, Tarras S, Taylor J, Vojtek AB |title=Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47922–7 |year= 2004 |pmid= 14504284 |doi= 10.1074/jbc.M307357200
*cite journal | author=Eckey M, Tenbaum SP, Muñoz A, Baniahmad A |title=Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 1 |pages= 71–8 |year= 2004 |pmid= 15062575 |doi= 10.1016/j.mce.2003.10.035
*cite journal | author=Jaffe AB, Hall A, Schmidt A |title=Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. |journal=Curr. Biol. |volume=15 |issue= 5 |pages= 405–12 |year= 2005 |pmid= 15753034 |doi= 10.1016/j.cub.2004.12.082
*cite journal | author=Kollers S, Musilova P, Rubes J, Rocha D |title=Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. |journal=Anim. Genet. |volume=37 |issue= 6 |pages= 595–6 |year= 2007 |pmid= 17121608 |doi= 10.1111/j.1365-2052.2006.01516.x

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