PRKACB

Protein kinase, cAMP-dependent, catalytic, beta, also known as PRKACB, is a human gene.cite web | title = Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5567| accessdate = ]

PBB_Summary
section_title =
summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: PRKACB protein kinase, cAMP-dependent, catalytic, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5567| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Simard J, Bérubé D, Sandberg M, "et al." |title=Assignment of the gene encoding the catalytic subunit C beta of cAMP-dependent protein kinase to the p36 band on chromosome 1. |journal=Hum. Genet. |volume=88 |issue= 6 |pages= 653–7 |year= 1992 |pmid= 1551670 |doi=
*cite journal | author=Hofmann B, Nishanian P, Baldwin RL, "et al." |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=
*cite journal | author=Beebe SJ, Oyen O, Sandberg M, "et al." |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465–75 |year= 1990 |pmid= 2342480 |doi=
*cite journal | author=Scarpetta MA, Uhler MD |title=Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse. |journal=J. Biol. Chem. |volume=268 |issue= 15 |pages= 10927–31 |year= 1993 |pmid= 7684369 |doi=
*cite journal | author=Hofmann B, Nishanian P, Nguyen T, "et al." |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=
*cite journal | author=Hofmann B, Nishanian P, Fan J, "et al." |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=
*cite journal | author=Gamm DM, Baude EJ, Uhler MD |title=The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo. |journal=J. Biol. Chem. |volume=271 |issue= 26 |pages= 15736–42 |year= 1996 |pmid= 8662989 |doi=
*cite journal | author=Swingler S, Gallay P, Camaur D, "et al." |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Liapi C, Takahashi N, Raynaud F, "et al." |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts. |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332–7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x
*cite journal | author=Rabbi MF, al-Harthi L, Saifuddin M, Roebuck KA |title=The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. |journal=Virology |volume=245 |issue= 2 |pages= 257–69 |year= 1998 |pmid= 9636365 |doi= 10.1006/viro.1998.9158
*cite journal | author=Zidovetzki R, Wang JL, Chen P, "et al." |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Jiang CH, Tsien JZ, Schultz PG, Hu Y |title=The effects of aging on gene expression in the hypothalamus and cortex of mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1930–4 |year= 2001 |pmid= 11172053 |doi= 10.1073/pnas.98.4.1930
*cite journal | author=Ørstavik S, Reinton N, Frengen E, "et al." |title=Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. |journal=Eur. J. Biochem. |volume=268 |issue= 19 |pages= 5066–73 |year= 2001 |pmid= 11589697 |doi=
*cite journal | author=Wu KJ, Mattioli M, Morse HC, Dalla-Favera R |title=c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. |journal=Oncogene |volume=21 |issue= 51 |pages= 7872–82 |year= 2002 |pmid= 12420224 |doi= 10.1038/sj.onc.1205986
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Higuchi H, Yamashita T, Yoshikawa H, Tohyama M |title=PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. |journal=EMBO J. |volume=22 |issue= 8 |pages= 1790–800 |year= 2003 |pmid= 12682012 |doi= 10.1093/emboj/cdg177
*cite journal | author=Gassel M, Breitenlechner CB, Rüger P, "et al." |title=Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). |journal=J. Mol. Biol. |volume=329 |issue= 5 |pages= 1021–34 |year= 2003 |pmid= 12798691 |doi=

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