MYLK

MYLK

Myosin, light chain kinase, also known as MYLK, is a human gene.

PBB_Summary
section_title =
summary_text = This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [cite web | title = Entrez Gene: MYLK myosin, light chain kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4638| accessdate = ]

ee also

* Myosin light-chain kinase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kamm KE, Stull JT |title=Dedicated myosin light chain kinases with diverse cellular functions. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4527–30 |year= 2001 |pmid= 11096123 |doi= 10.1074/jbc.R000028200

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • mylk — milk (2) …   Dictionary of ichthyology

  • Miosina cadena ligera kinasa — Miosina cadena ligera kinasa[1] Estructura de la MYLK. HUGO …   Wikipedia Español

  • Myosin light-chain kinase — myosin light polypeptide kinase, smooth muscle Identifiers Symbol MYLK Entrez 4638 HUGO …   Wikipedia

  • Myosin — Part of the myosin II structure. Atoms in the heavy chain are colored red on the left hand side, and atoms in the light chains are colored orange and yellow. Myosins comprise a family of ATP dependent motor proteins and are best known for their… …   Wikipedia

  • Titin — The three dimensional structure of a type I module from titin. PDB rendering based on 1bpv …   Wikipedia

  • Myosin light chain — Part of the myosin II structure. Atoms in the heavy chain are colored red on the left hand side, and atoms in the light chains are colored orange and yellow. Myosin light chain is a subunit of myosin [1] Myosin light chains are distinct and have… …   Wikipedia

  • Myosin-leichte-Ketten-Kinase — Masse/Länge Primärstruktur 1914 Aminosäuren …   Deutsch Wikipedia

  • Microtubule — Space filling model of a microtubule segment derived from cryo electron microscopy. The protofilaments are seen running along the axis of the segment. The microtubule (+) end is towards the top of the image.[1] Microtubules are a component of the …   Wikipedia

  • Keratin — Not to be confused with kerogen, carotene, chitin, or creatine. Microscopy of keratin filaments inside cells. Keratin refers to a family of fibrous structural proteins. Keratin is the key structural material making up the outer layer of human… …   Wikipedia

  • Cytoskeleton — The eukaryotic cytoskeleton. Actin filaments are shown in red, microtubules in green, and the nuclei are in blue. The cytoskeleton (also CSK) is a cellular scaffolding or skeleton contained within a cell s cytoplasm and is made out of protein.… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”