- Kalirin
protein
Name=kalirin, RhoGEF kinase
caption=
width=
HGNCid=4814
Symbol=KALRN
AltSymbols=HAPIP
EntrezGene=8997
OMIM=604605
RefSeq=NM_003947
UniProt=O60229
PDB=
ECnumber=
Chromosome=3
Arm=q
Band=21.2
LocusSupplementaryData=Kalirin (other names: huntingtin-associated protein interacting protein, HAPIP; DUO) is a member of Dbl family of proteins and a Rho guanine nucleotide exchange factor. It is named after the multiple-handed Hindu goddess Kali for its ability to interact with numerous other proteins. Kalirin's other name, DUO, comes from the fact that it is 98% identical to rat DUO protein and 80.6% identical to a human protein named TRIO. Unlike TRIO, which is expressed in numerous tissues, Kalirin isoforms are mainly found in the brain. Kalirin was first identified in
1997 as a protein interacting withhuntingtin-associated protein 1 . cite journal |author=Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, Lyford G, Worley P, Ross CA |title=Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain |journal=Hum. Mol. Genet. |volume=6 |issue=9 |pages=1519–25 |year=1997 |pmid=9285789 |doi=]Several isoforms of Kalirin are produced through
alternative splicing . cite journal |author=McPherson CE, Eipper BA, Mains RE |title=Genomic organization and differential expression of Kalirin isoforms |journal=Gene |volume=284 |issue=1-2 |pages=41–51 |year=2002 |pmid=11891045 |doi=] One of the isoforms, Kalirin-7, was found to be necessary for the remodeling of synapses in mature cortical neurons. cite journal |author=Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, Shum CY, Surmeier DJ, Penzes P |title=Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines |journal=Neuron |volume=56 |issue=4 |pages=640–56 |year=2007 |pmid=18031682 |doi=10.1016/j.neuron.2007.10.005] Pat McCaffrey. [http://www.schizophreniaforum.org/new/detail.asp?id=1408 Architect of Synaptic Plasticity Links Spine Form and Function] - Schizophrenia Research Forum, 2007-11-30.]Biological Function of Kalirin
Kalirin is known to play an important role in nerve growth and axonal development. [Molecular and Cellular Biology, June 2005, p. 5106-5118, Vol. 25, No. 120270-7306/05/$08.00+0 doi:10.1128/MCB.25.12.5106-5118.2005 Critical Role for Kalirin in Nerve Growth Factor Signaling through TrkA]
References
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