PHKG1

Phosphorylase kinase, gamma 1 (muscle), also known as PHKG1, is a human gene.cite web | title = Entrez Gene: PHKG1 phosphorylase kinase, gamma 1 (muscle)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5260| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12.cite web | title = Entrez Gene: PHKG1 phosphorylase kinase, gamma 1 (muscle)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5260| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jones TA, da Cruz e Silva EF, Spurr NK, "et al." |title=Localisation of the gene encoding the catalytic gamma subunit of phosphorylase kinase to human chromosome bands 7p12-q21. |journal=Biochim. Biophys. Acta |volume=1048 |issue= 1 |pages= 24–9 |year= 1990 |pmid= 2297530 |doi=
*cite journal | author=Harris WR, Malencik DA, Johnson CM, "et al." |title=Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain. |journal=J. Biol. Chem. |volume=265 |issue= 20 |pages= 11740–5 |year= 1990 |pmid= 2365696 |doi=
*cite journal | author=Dasgupta M, Honeycutt T, Blumenthal DK |title=The gamma-subunit of skeletal muscle phosphorylase kinase contains two noncontiguous domains that act in concert to bind calmodulin. |journal=J. Biol. Chem. |volume=264 |issue= 29 |pages= 17156–63 |year= 1989 |pmid= 2507540 |doi=
*cite journal | author=Drewes G, Trinczek B, Illenberger S, "et al." |title=Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7679–88 |year= 1995 |pmid= 7706316 |doi=
*cite journal | author=Wehner M, Clemens PR, Engel AG, Kilimann MW |title=Human muscle glycogenosis due to phosphorylase kinase deficiency associated with a nonsense mutation in the muscle isoform of the alpha subunit. |journal=Hum. Mol. Genet. |volume=3 |issue= 11 |pages= 1983–7 |year= 1995 |pmid= 7874115 |doi=
*cite journal | author=Yuan CJ, Huang CY, Graves DJ |title=Oxidation and site-directed mutagenesis of the sulfhydryl groups of a truncated gamma catalytic subunit of phosphorylase kinase. Functional and structural effects. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 24367–73 |year= 1994 |pmid= 7929096 |doi=
*cite journal | author=Malencik DA, Zhao Z, Anderson SR |title=Preparation and functional characterization of a catalytically active fragment of phosphorylase kinase. |journal=Mol. Cell. Biochem. |volume=127-128 |issue= |pages= 31–43 |year= 1994 |pmid= 7935360 |doi=
*cite journal | author=Wehner M, Kilimann MW |title=Human cDNA encoding the muscle isoform of the phosphorylase kinase gamma subunit (PHKG1). |journal=Hum. Genet. |volume=96 |issue= 5 |pages= 616–8 |year= 1996 |pmid= 8530014 |doi=
*cite journal | author=Steiner RF, Juminaga D, Albaugh S, Washington H |title=A comparison of the properties of the binary and ternary complexes formed by calmodulin and troponin C with two regulatory peptides of phosphorylase kinase. |journal=Biophys. Chem. |volume=59 |issue= 3 |pages= 277–88 |year= 1996 |pmid= 8672716 |doi=
*cite journal | author=Paudel HK |title=The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1777–85 |year= 1997 |pmid= 8999860 |doi=
*cite journal | author=Lowe ED, Noble ME, Skamnaki VT, "et al." |title=The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. |journal=EMBO J. |volume=16 |issue= 22 |pages= 6646–58 |year= 1998 |pmid= 9362479 |doi= 10.1093/emboj/16.22.6646
*cite journal | author=Sengupta A, Kabat J, Novak M, "et al." |title=Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. |journal=Arch. Biochem. Biophys. |volume=357 |issue= 2 |pages= 299–309 |year= 1998 |pmid= 9735171 |doi= 10.1006/abbi.1998.0813
*cite journal | author=Wang JZ, Wu Q, Smith A, "et al." |title=Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. |journal=FEBS Lett. |volume=436 |issue= 1 |pages= 28–34 |year= 1998 |pmid= 9771888 |doi=
*cite journal | author=Hanger DP, Betts JC, Loviny TL, "et al." |title=New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. |journal=J. Neurochem. |volume=71 |issue= 6 |pages= 2465–76 |year= 1998 |pmid= 9832145 |doi=
*cite journal | author=Schneider A, Biernat J, von Bergen M, "et al." |title=Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. |journal=Biochemistry |volume=38 |issue= 12 |pages= 3549–58 |year= 1999 |pmid= 10090741 |doi= 10.1021/bi981874p
*cite journal | author=Reynolds CH, Betts JC, Blackstock WP, "et al." |title=Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta. |journal=J. Neurochem. |volume=74 |issue= 4 |pages= 1587–95 |year= 2000 |pmid= 10737616 |doi=
*cite journal | author=Liu F, Iqbal K, Grundke-Iqbal I, Gong CX |title=Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. |journal=FEBS Lett. |volume=530 |issue= 1-3 |pages= 209–14 |year= 2002 |pmid= 12387894 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Burwinkel B, Hu B, Schroers A, "et al." |title=Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases. |journal=Eur. J. Hum. Genet. |volume=11 |issue= 7 |pages= 516–26 |year= 2004 |pmid= 12825073 |doi= 10.1038/sj.ejhg.5200996

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