CAMK2A

Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, also known as CAMK2A, is a human gene.

PBB_Summary
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summary_text = The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [cite web | title = Entrez Gene: CAMK2A calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=815| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Soderling TR |title=CaM-kinases: modulators of synaptic plasticity. |journal=Curr. Opin. Neurobiol. |volume=10 |issue= 3 |pages= 375–80 |year= 2000 |pmid= 10851169 |doi=
*cite journal | author=Hook SS, Means AR |title=Ca(2+)/CaM-dependent kinases: from activation to function. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=41 |issue= |pages= 471–505 |year= 2001 |pmid= 11264466 |doi= 10.1146/annurev.pharmtox.41.1.471
*cite journal | author=Yamamoto H |title= [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 3 |pages= 241–7 |year= 2002 |pmid= 11889801 |doi=
*cite journal | author=Countaway JL, Nairn AC, Davis RJ |title=Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 1129–40 |year= 1992 |pmid= 1309762 |doi=
*cite journal | author=Wegner M, Cao Z, Rosenfeld MG |title=Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. |journal=Science |volume=256 |issue= 5055 |pages= 370–3 |year= 1992 |pmid= 1314426 |doi=
*cite journal | author=Omary MB, Baxter GT, Chou CF, "et al." |title=PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. |journal=J. Cell Biol. |volume=117 |issue= 3 |pages= 583–93 |year= 1992 |pmid= 1374067 |doi=
*cite journal | author=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |pmid= 1375933 |doi=
*cite journal | author=Tokui T, Yamauchi T, Yano T, "et al." |title=Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins. |journal=Biochem. Biophys. Res. Commun. |volume=169 |issue= 3 |pages= 896–904 |year= 1990 |pmid= 2114109 |doi=
*cite journal | author=Inagaki M, Gonda Y, Nishizawa K, "et al." |title=Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain. |journal=J. Biol. Chem. |volume=265 |issue= 8 |pages= 4722–9 |year= 1990 |pmid= 2155236 |doi=
*cite journal | author=Ohta Y, Ohba T, Miyamoto E |title=Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 14 |pages= 5341–5 |year= 1990 |pmid= 2164678 |doi=
*cite journal | author=Lee RH, Brown BM, Lolley RN |title=Protein kinase A phosphorylates retinal phosducin on serine 73 in situ. |journal=J. Biol. Chem. |volume=265 |issue= 26 |pages= 15860–6 |year= 1990 |pmid= 2394752 |doi=
*cite journal | author=Lin CR, Kapiloff MS, Durgerian S, "et al." |title=Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 16 |pages= 5962–6 |year= 1987 |pmid= 3475713 |doi=
*cite journal | author=Ku NO, Omary MB |title=Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. |journal=J. Cell Biol. |volume=127 |issue= 1 |pages= 161–71 |year= 1994 |pmid= 7523419 |doi=
*cite journal | author=Drewes G, Trinczek B, Illenberger S, "et al." |title=Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7679–88 |year= 1995 |pmid= 7706316 |doi=
*cite journal | author=Tsujimura K, Tanaka J, Ando S, "et al." |title=Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II. |journal=J. Biochem. |volume=116 |issue= 2 |pages= 426–34 |year= 1995 |pmid= 7822264 |doi=
*cite journal | author=Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan DH |title=Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 26492–6 |year= 1994 |pmid= 7929371 |doi=
*cite journal | author=Rivera VM, Miranti CK, Misra RP, "et al." |title=A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6260–73 |year= 1993 |pmid= 8413226 |doi=
*cite journal | author=Omkumar RV, Kiely MJ, Rosenstein AJ, "et al." |title=Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31670–8 |year= 1997 |pmid= 8940188 |doi=
*cite journal | author=Rotenberg A, Mayford M, Hawkins RD, "et al." |title=Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. |journal=Cell |volume=87 |issue= 7 |pages= 1351–61 |year= 1997 |pmid= 8980240 |doi=
*cite journal | author=Paudel HK |title=The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1777–85 |year= 1997 |pmid= 8999860 |doi=

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