Name=Bone morphogenetic protein receptor, type IB
Gene = HUGO code: [ BMPR1B]
Structure =
Review =
Type= Receptor serine/threonine kinase
Domains= TM domain S/T domain, GS domain
Diseases=Acromesomelic chondrodysplasia with genital anomalies OMIM|609441; Brachydactyly type A2 (BDA2) OMIM|112600
Taxa = Homo sapiens: homologs: many metazoan phyla
Cells = many
Location =Plasma membrane
Catalytic_activity=ATP + (receptor-protein) = ADP + receptor-protein phosphate
Cofactors=Magnesium or manganese
Names= CDw293 antigen
The BMPR1B receptor plays a role in the formation of middle and proximal phalanges.cite journal | author = Mishina Y, Starbuck MW, Gentile MA, Fukuda T, Kasparcova V, Seedor JG, Hanks MC, Amling M, Pinero GJ, Harada S, Behringer RR | title = Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling | journal = J. Biol. Chem. | volume = 279 | issue = 26 | pages = 27560–6 | year = 2004 | pmid = 15090551 | doi = 10.1074/jbc.M404222200 | issn = ] BMPR1B has also been designated as CDw293 (cluster of differentiation w293).

In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations.cite journal | author = Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM | title = Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 14 | pages = 5062–7 | year = 2005 | pmid = 15781876 | doi = 10.1073/pnas.0500031102 | issn = ] BMPR1B is the major transducer of signals in these condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.


External links


Category:S/T domain

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