BMPR1B

BMPR1B

Protbox
Name=Bone morphogenetic protein receptor, type IB
Photo=
Caption=
Gene = HUGO code: [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:1077 BMPR1B]
Structure =
Review =
Type= Receptor serine/threonine kinase
Functions=
Domains= TM domain S/T domain, GS domain
Diseases=Acromesomelic chondrodysplasia with genital anomalies OMIM|609441; Brachydactyly type A2 (BDA2) OMIM|112600
Taxa = Homo sapiens: homologs: many metazoan phyla
Cells = many
Location =Plasma membrane
Catalytic_activity=ATP + (receptor-protein) = ADP + receptor-protein phosphate
Cofactors=Magnesium or manganese
Enzyme_regulation=
Actions=
Agonists=
Antagonists=
Mods=
Names= CDw293 antigen
Interactions=
Pages=
The BMPR1B receptor plays a role in the formation of middle and proximal phalanges.cite journal | author = Mishina Y, Starbuck MW, Gentile MA, Fukuda T, Kasparcova V, Seedor JG, Hanks MC, Amling M, Pinero GJ, Harada S, Behringer RR | title = Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling | journal = J. Biol. Chem. | volume = 279 | issue = 26 | pages = 27560–6 | year = 2004 | pmid = 15090551 | doi = 10.1074/jbc.M404222200 | issn = ] BMPR1B has also been designated as CDw293 (cluster of differentiation w293).

In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations.cite journal | author = Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM | title = Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 14 | pages = 5062–7 | year = 2005 | pmid = 15781876 | doi = 10.1073/pnas.0500031102 | issn = ] BMPR1B is the major transducer of signals in these condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

References

External links

*

Category:S/T domain


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • BMPR1A — Protbox Name=Bone morphogenetic protein receptor, type IA Photo=BMPR1A.png Caption=Ternary Complex Of Bmp 2 Bound To Bmpr Ia Ecd And Actrii Ecd HGNCid = Symbol = AltSymbols = Names=Serine/threonine protein kinase receptor R5, SKR5, Activin… …   Wikipedia

  • Brachydactyly — Classification and external resources Different forms of brachydactyly ICD 10 Q68 …   Wikipedia

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia

  • Guanylate cyclase — (EC 4.6.1.2, also known as guanylyl cyclase, guanyl cyclase or GC) is a lyase enzyme. Contents 1 Reaction 2 Types 3 Function …   Wikipedia

  • Cyclin-dependent kinase — Schematic of the cell cycle. outer ring: I=Interphase, M=Mitosis; inner ring: M=Mitosis; G1=Gap phase 1; S=Synthesis; G2=Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent… …   Wikipedia

  • Myostatin — Identifiers Symbols MSTN; GDF8 External IDs OMIM:  …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • Anti-Müllerian hormone — Identifiers Symbol AMH Entrez 268 HUGO …   Wikipedia

  • Titin — The three dimensional structure of a type I module from titin. PDB rendering based on 1bpv …   Wikipedia

  • PDK1 — Not to be confused with the master kinase PDK1, 3 phosphoinositide dependent protein kinase (PDPK1). Pyruvate dehydrogenase kinase, isozyme 1 Rendering based on PDB …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”