- RPS6KA4
Ribosomal protein S6 kinase, 90kDa, polypeptide 4, also known as RPS6KA4, is a human
gene .cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8986| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959–63 |year= 1996 |pmid= 8688081 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426–41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426
*cite journal | author=Pierrat B, Correia JS, Mary JL, "et al." |title=RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29661–71 |year= 1998 |pmid= 9792677 |doi=
*cite journal | author=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377–9 |year= 1999 |pmid= 9829964 |doi=
*cite journal | author=Zhu S, Gerhard DS |title=A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 674–80 |year= 1999 |pmid= 9921902 |doi=
*cite journal | author=Tomás-Zuber M, Mary JL, Lesslauer W |title=Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23549–58 |year= 2000 |pmid= 10806207 |doi= 10.1074/jbc.M002586200
*cite journal | author=Tomás-Zuber M, Mary JL, Lamour F, "et al." |title=C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB). |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5892–9 |year= 2001 |pmid= 11035004 |doi= 10.1074/jbc.M005822200
*cite journal | author=Gudi T, Casteel DE, Vinson C, "et al." |title=NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. |journal=Oncogene |volume=19 |issue= 54 |pages= 6324–33 |year= 2001 |pmid= 11175347 |doi= 10.1038/sj.onc.1204007
*cite journal | author=Prymakowska-Bosak M, Misteli T, Herrera JE, "et al." |title=Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5169–78 |year= 2001 |pmid= 11438671 |doi= 10.1128/MCB.21.15.5169-5178.2001
*cite journal | author=Wiggin GR, Soloaga A, Foster JM, "et al." |title=MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2871–81 |year= 2002 |pmid= 11909979 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Soloaga A, Thomson S, Wiggin GR, "et al." |title=MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2788–97 |year= 2003 |pmid= 12773393 |doi= 10.1093/emboj/cdg273
*cite journal | author=Wissing J, Jänsch L, Nimtz M, "et al." |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200
*cite journal | author=Gesser B, Johansen C, Rasmussen MK, "et al." |title=Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect. |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2129–37 |year= 2007 |pmid= 17495961 |doi= 10.1038/sj.jid.5700859PBB_Controls
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