MAPKAPK5

Mitogen-activated protein kinase-activated protein kinase 5, also known as MAPKAPK5, is a human gene.cite web | title = Entrez Gene: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8550| accessdate = ] PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.cite web | title = Entrez Gene: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8550| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=de Carvalho MG, McCormack AL, Olson E, "et al." |title=Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6987–97 |year= 1996 |pmid= 8636128 |doi=
*cite journal | author=Börsch-Haubold AG, Bartoli F, Asselin J, "et al." |title=Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4449–58 |year= 1998 |pmid= 9468497 |doi=
*cite journal | author=Ni H, Wang XS, Diener K, Yao Z |title=MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 492–6 |year= 1998 |pmid= 9480836 |doi= 10.1006/bbrc.1998.8135
*cite journal | author=New L, Jiang Y, Zhao M, "et al." |title=PRAK, a novel protein kinase regulated by the p38 MAP kinase. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3372–84 |year= 1998 |pmid= 9628874 |doi= 10.1093/emboj/17.12.3372
*cite journal | author=Sudo T, Maruyama M, Osada H |title=p62 functions as a p38 MAP kinase regulator. |journal=Biochem. Biophys. Res. Commun. |volume=269 |issue= 2 |pages= 521–5 |year= 2000 |pmid= 10708586 |doi= 10.1006/bbrc.2000.2333
*cite journal | author=Hefner Y, Borsch-Haubold AG, Murakami M, "et al." |title=Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37542–51 |year= 2001 |pmid= 10978317 |doi= 10.1074/jbc.M003395200
*cite journal | author=Zhou J, Lottenbach KR, Barenkamp SJ, "et al." |title=Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F. |journal=Infect. Immun. |volume=70 |issue= 8 |pages= 4083–91 |year= 2002 |pmid= 12117915 |doi=
*cite journal | author=Perfetti V, Casarini S, Palladini G, "et al." |title=Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment. |journal=Blood |volume=100 |issue= 3 |pages= 948–53 |year= 2002 |pmid= 12130507 |doi= 10.1182/blood-2002-01-0114
*cite journal | author=Knebel A, Haydon CE, Morrice N, Cohen P |title=Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 525–32 |year= 2002 |pmid= 12171600 |doi= 10.1042/BJ20020916
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=New L, Jiang Y, Han J |title=Regulation of PRAK subcellular location by p38 MAP kinases. |journal=Mol. Biol. Cell |volume=14 |issue= 6 |pages= 2603–16 |year= 2004 |pmid= 12808055 |doi= 10.1091/mbc.E02-08-0538
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Sun P, Yoshizuka N, New L, "et al." |title=PRAK is essential for ras-induced senescence and tumor suppression. |journal=Cell |volume=128 |issue= 2 |pages= 295–308 |year= 2007 |pmid= 17254968 |doi= 10.1016/j.cell.2006.11.050

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