MAPK8IP1

Mitogen-activated protein kinase 8 interacting protein 1, also known as MAPK8IP1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.cite web | title = Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9479| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Dickens M, Rogers JS, Cavanagh J, "et al." |title=A cytoplasmic inhibitor of the JNK signal transduction pathway. |journal=Science |volume=277 |issue= 5326 |pages= 693–6 |year= 1997 |pmid= 9235893 |doi=
*cite journal | author=Bonny C, Nicod P, Waeber G |title=IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 1843–6 |year= 1998 |pmid= 9442013 |doi=
*cite journal | author=Whitmarsh AJ, Cavanagh J, Tournier C, "et al." |title=A mammalian scaffold complex that selectively mediates MAP kinase activation. |journal=Science |volume=281 |issue= 5383 |pages= 1671–4 |year= 1998 |pmid= 9733513 |doi=
*cite journal | author=Mooser V, Maillard A, Bonny C, "et al." |title=Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. |journal=Genomics |volume=55 |issue= 2 |pages= 202–8 |year= 1999 |pmid= 9933567 |doi= 10.1006/geno.1998.5641
*cite journal | author=Yasuda J, Whitmarsh AJ, Cavanagh J, "et al." |title=The JIP group of mitogen-activated protein kinase scaffold proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7245–54 |year= 2000 |pmid= 10490659 |doi=
*cite journal | author=Meyer D, Liu A, Margolis B |title=Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 35113–8 |year= 2000 |pmid= 10574993 |doi=
*cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=
*cite journal | author=Waeber G, Delplanque J, Bonny C, "et al." |title=The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. |journal=Nat. Genet. |volume=24 |issue= 3 |pages= 291–5 |year= 2000 |pmid= 10700186 |doi= 10.1038/73523
*cite journal | author=Bonny C, Oberson A, Steinmann M, "et al." |title=IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16466–72 |year= 2000 |pmid= 10748095 |doi= 10.1074/jbc.M908297199
*cite journal | author=Gotthardt M, Trommsdorff M, Nevitt MF, "et al." |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616–24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200
*cite journal | author=Bonny C, Oberson A, Negri S, "et al." |title=Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. |journal=Diabetes |volume=50 |issue= 1 |pages= 77–82 |year= 2001 |pmid= 11147798 |doi=
*cite journal | author=Verhey KJ, Meyer D, Deehan R, "et al." |title=Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. |journal=J. Cell Biol. |volume=152 |issue= 5 |pages= 959–70 |year= 2001 |pmid= 11238452 |doi=
*cite journal | author=Matsuda S, Yasukawa T, Homma Y, "et al." |title=c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. |journal=J. Neurosci. |volume=21 |issue= 17 |pages= 6597–607 |year= 2001 |pmid= 11517249 |doi=
*cite journal | author=Abderrahmani A, Steinmann M, Plaisance V, "et al." |title=The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1). |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7256–67 |year= 2001 |pmid= 11585908 |doi= 10.1128/MCB.21.21.7256-7267.2001
*cite journal | author=Cai Y, Lechner MS, Nihalani D, "et al." |title=Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1217–22 |year= 2002 |pmid= 11700324 |doi= 10.1074/jbc.M109663200
*cite journal | author=Scheinfeld MH, Roncarati R, Vito P, "et al." |title=Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3767–75 |year= 2002 |pmid= 11724784 |doi= 10.1074/jbc.M108357200
*cite journal | author=Ikeda A, Hasegawa K, Masaki M, "et al." |title=Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. |journal=J. Biochem. |volume=130 |issue= 6 |pages= 773–81 |year= 2002 |pmid= 11726277 |doi=
*cite journal | author=Hashimoto M, Hsu LJ, Rockenstein E, "et al." |title=alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11465–72 |year= 2002 |pmid= 11790792 |doi= 10.1074/jbc.M111428200

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