MAPK8IP2

Mitogen-activated protein kinase 8 interacting protein 2, also known as MAPK8IP2, is a human gene.cite web | title = Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23542| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.cite web | title = Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23542| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Yasuda J, Whitmarsh AJ, Cavanagh J, "et al." |title=The JIP group of mitogen-activated protein kinase scaffold proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7245–54 |year= 2000 |pmid= 10490659 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=
*cite journal | author=Negri S, Oberson A, Steinmann M, "et al." |title=cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. |journal=Genomics |volume=64 |issue= 3 |pages= 324–30 |year= 2000 |pmid= 10756100 |doi= 10.1006/geno.2000.6129
*cite journal | author=Gotthardt M, Trommsdorff M, Nevitt MF, "et al." |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616–24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200
*cite journal | author=Schoorlemmer J, Goldfarb M |title=Fibroblast growth factor homologous factors are intracellular signaling proteins. |journal=Curr. Biol. |volume=11 |issue= 10 |pages= 793–7 |year= 2001 |pmid= 11378392 |doi=
*cite journal | author=Taru H, Kirino Y, Suzuki T |title=Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27567–74 |year= 2002 |pmid= 12023290 |doi= 10.1074/jbc.M203713200
*cite journal | author=Buchsbaum RJ, Connolly BA, Feig LA |title=Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4073–85 |year= 2002 |pmid= 12024021 |doi=
*cite journal | author=Schoorlemmer J, Goldfarb M |title=Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49111–9 |year= 2003 |pmid= 12244047 |doi= 10.1074/jbc.M205520200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Willoughby EA, Perkins GR, Collins MK, Whitmarsh AJ |title=The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10731–6 |year= 2003 |pmid= 12524447 |doi= 10.1074/jbc.M207324200
*cite journal | author=Collins JE, Goward ME, Cole CG, "et al." |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kristensen O, Guenat S, Dar I, "et al." |title=A unique set of SH3-SH3 interactions controls IB1 homodimerization. |journal=EMBO J. |volume=25 |issue= 4 |pages= 785–97 |year= 2006 |pmid= 16456539 |doi= 10.1038/sj.emboj.7600982

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