ADAMTS4

ADAM metallopeptidase with thrombospondin type 1 motif, 4, also known as ADAMTS4, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.cite web | title = Entrez Gene: ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9507| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tang BL, Hong W |title=ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. |journal=FEBS Lett. |volume=445 |issue= 2-3 |pages= 223–5 |year= 1999 |pmid= 10094461 |doi=
*cite journal | author=Tang BL |title=ADAMTS: a novel family of extracellular matrix proteases. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 1 |pages= 33–44 |year= 2001 |pmid= 11167130 |doi=
*cite journal | author=Hirohata S |title= [ADAMTS family--new extracellular matrix degrading enzyme] |journal=Seikagaku |volume=73 |issue= 11 |pages= 1333–7 |year= 2002 |pmid= 11831030 |doi=
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Tortorella MD, Burn TC, Pratta MA, "et al." |title=Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. |journal=Science |volume=284 |issue= 5420 |pages= 1664–6 |year= 1999 |pmid= 10356395 |doi=
*cite journal | author=Abbaszade I, Liu RQ, Yang F, "et al." |title=Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. |journal=J. Biol. Chem. |volume=274 |issue= 33 |pages= 23443–50 |year= 1999 |pmid= 10438522 |doi=
*cite journal | author=Hurskainen TL, Hirohata S, Seldin MF, Apte SS |title=ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25555–63 |year= 1999 |pmid= 10464288 |doi=
*cite journal | author=Tortorella MD, Pratta M, Liu RQ, "et al." |title=Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4). |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18566–73 |year= 2000 |pmid= 10751421 |doi= 10.1074/jbc.M909383199
*cite journal | author=Matthews RT, Gary SC, Zerillo C, "et al." |title=Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22695–703 |year= 2000 |pmid= 10801887 |doi= 10.1074/jbc.M909764199
*cite journal | author=Tortorella M, Pratta M, Liu RQ, "et al." |title=The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25791–7 |year= 2000 |pmid= 10827174 |doi= 10.1074/jbc.M001065200
*cite journal | author=Nakamura H, Fujii Y, Inoki I, "et al." |title=Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38885–90 |year= 2001 |pmid= 10986281 |doi= 10.1074/jbc.M003875200
*cite journal | author=Mizui Y, Yamazaki K, Kuboi Y, "et al." |title=Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene. |journal=Mol. Biol. Rep. |volume=27 |issue= 3 |pages= 167–73 |year= 2001 |pmid= 11254106 |doi=
*cite journal | author=Sandy JD, Westling J, Kenagy RD, "et al." |title=Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13372–8 |year= 2001 |pmid= 11278559 |doi= 10.1074/jbc.M009737200
*cite journal | author=Gao G, Westling J, Thompson VP, "et al." |title=Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11034–41 |year= 2002 |pmid= 11796708 |doi= 10.1074/jbc.M107443200
*cite journal | author=Yamanishi Y, Boyle DL, Clark M, "et al." |title=Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. |journal=J. Immunol. |volume=168 |issue= 3 |pages= 1405–12 |year= 2002 |pmid= 11801682 |doi=
*cite journal | author=Westling J, Fosang AJ, Last K, "et al." |title=ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16059–66 |year= 2002 |pmid= 11854269 |doi= 10.1074/jbc.M108607200
*cite journal | author=Malfait AM, Liu RQ, Ijiri K, "et al." |title=Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22201–8 |year= 2002 |pmid= 11956193 |doi= 10.1074/jbc.M200431200

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