Collagenase

matrix metallopeptidase 1 (interstitial collagenase)
Identifiers
Symbol	MMP1
Entrez	4312
HUGO	7155
OMIM	120353
RefSeq	NM_002421
UniProt	P03956
Other data
EC number	3.4.24.7
Locus	Chr. 11 q21-q22

matrix metallopeptidase 8 (neutrophil collagenase)
Identifiers
Symbol	MMP8
Entrez	4317
HUGO	7175
OMIM	120355
RefSeq	NM_002424
UniProt	P22894
Other data
EC number	3.4.24.34
Locus	Chr. 11 q21-q22

Collagenases are enzymes that break the peptide bonds in collagen.

They assist in destroying extracellular structures in pathogenesis of bacteria such as Clostridium. They are an exotoxin (a virulence factor) and help to facilitate the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.^[1]

Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.

Collagenase production can be induced during an immune response, by cytokines that stimulate cells such as fibroblasts and osteoblasts, and cause indirect tissue damage.^{[citation needed]}

Therapeutic uses

Collagenases have been approved for medical uses for

• treatment of Dupuytren's contracture (Xiaflex).

Collagenases and Peyronie's disease

Collagenase remains an investigational drug for the treatment of Peyronie's disease. ^[2] It has presented a documented efficiency in reducing the size of plaques or in some cases eliminating them.^[3]

See also

• Matrix metalloproteinase
• Gas gangrene

References

1. ^ Gerard J. Tortora, Berdell R. Funke, Cristine L. Case (2007). Microbiology: an introduction. Pearson Benjamin Cummings. ISBN 03-213-960-30. 
2. ^ http://www.peyronies.org/pages/treatment.htm
3. ^ http://www.andrologyjournal.org/cgi/content/full/30/4/397

External links

• MeSH Collagenases

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Genes on chromosome 11 EC 3.4.24 Hydrolase stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Ashton, Gardner and Dyke Sabana Grande de Palenque Look at other dictionaries: Collagenase — Collagénase Les collagénases sont des enzymes capables de rompre les liaisons peptidiques du collagène. Elles facilitent la destruction des structures extracellulaires lors de la pathogenèse bactérienne. Ce sont des exotoxines. La production de… …   Wikipédia en Français collagenase — collagenase. См. коллагеназа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь. Collagenase clostridium histolyticum — Clinical data Pregnancy cat. B(US) Legal status ℞ Prescription only Routes Intralesional injection …   Wikipedia collagenase A, collagenase I — SYN: Clostridium histolyticum collagenase …   Medical dictionary collagenase — noun Date: 1926 any of a group of proteolytic enzymes that decompose collagen and gelatin …   New Collegiate Dictionary Collagénase — Les collagénases sont des enzymes capables de rompre les liaisons peptidiques du collagène. Elles facilitent la destruction des structures extracellulaires lors de la pathogenèse bactérienne. Ce sont des exotoxines. La production de collagénases… …   Wikipédia en Français collagenase — n. [Gr. kolla, glue; genos, to produce; asis, denoting enzymes] A proteolytic digestive enzyme …   Dictionary of invertebrate zoology collagenase — Proteolytic enzyme capable of breaking native collagen. Once the initial cleavage is made, less specific proteases will complete the degradation. Collagenases from mammalian cells are metallo enzymes and are collagen type specific. May be… …   Dictionary of molecular biology collagenase — col·lag·e·nase (kə lăjʹə nās , nāz , kŏlʹə jə ) n. Any of various enzymes that catalyze the hydrolysis of collagen and gelatin. * * * …   Universalium collagenase — noun An enzyme that breaks the peptide bonds in collagen …   Wiktionary 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”