- ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10, also known as ADAMTS10, is a human
gene .cite web | title = Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81794| accessdate = ]PBB_Summary
section_title =
summary_text = This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.cite web | title = Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81794| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tang BL |title=ADAMTS: a novel family of extracellular matrix proteases. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 1 |pages= 33–44 |year= 2001 |pmid= 11167130 |doi=
*cite journal | author=Faivre L, Dollfus H, Lyonnet S, "et al." |title=Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome. |journal=Am. J. Med. Genet. A |volume=123 |issue= 2 |pages= 204–7 |year= 2004 |pmid= 14598350 |doi= 10.1002/ajmg.a.20289
*cite journal | author=Apte SS |title=A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 6 |pages= 981–5 |year= 2004 |pmid= 15094112 |doi= 10.1016/j.biocel.2004.01.014
*cite journal | author=Faivre L, Mégarbané A, Alswaid A, "et al." |title=Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2. |journal=Hum. Genet. |volume=110 |issue= 4 |pages= 366–70 |year= 2002 |pmid= 11941487 |doi= 10.1007/s00439-002-0689-3
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Fu GK, Wang JT, Yang J, "et al." |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011
*cite journal | author=Somerville RP, Jungers KA, Apte SS |title=Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51208–17 |year= 2005 |pmid= 15355968 |doi= 10.1074/jbc.M409036200
*cite journal | author=Charrier L, Yan Y, Driss A, "et al." |title=ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 2 |pages= G346–53 |year= 2005 |pmid= 15358598 |doi= 10.1152/ajpgi.00262.2004
*cite journal | author=Dagoneau N, Benoist-Lasselin C, Huber C, "et al." |title=ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome. |journal=Am. J. Hum. Genet. |volume=75 |issue= 5 |pages= 801–6 |year= 2005 |pmid= 15368195 |doi= 10.1086/425231PBB_Controls
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