MMP14

Matrix metallopeptidase 14 (membrane-inserted)
PDB rendering based on 1bqq.
Available structures PDB 1BQQ, 1BUV, 3C7X, 3MA2
Identifiers
Symbols	MMP14; 1; MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1
External IDs	OMIM: 600754 MGI: 101900 HomoloGene: 21040 GeneCards: MMP14 Gene
EC number	3.4.24.80
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • metalloendopeptidase activity • integrin binding • calcium ion binding • protein binding • zinc ion binding • peptidase activator activity Cellular component • cytoplasm • integral to plasma membrane • membrane • extracellular matrix • melanosome Biological process • ossification • angiogenesis • ovarian follicle development • response to hypoxia • endothelial cell proliferation • proteolysis • response to oxidative stress • metabolic process • response to mechanical stimulus • response to hormone stimulus • response to organic cyclic compound • cell migration • lung development • zymogen activation • astrocyte cell migration • response to estrogen stimulus • branching morphogenesis of a tube • tissue remodeling • negative regulation of focal adhesion assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4323	17387
Ensembl	ENSG00000157227	ENSMUSG00000000957
UniProt	P50281	Q3TQH0
RefSeq (mRNA)	NM_004995.2	NM_008608.3
RefSeq (protein)	NP_004986.1	NP_032634.3
Location (UCSC)	Chr 14: 23.31 – 23.32 Mb	Chr 14: 55.05 – 55.06 Mb
PubMed search	[1]	[2]

Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.^[1]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. "This protein activates MMP2 protein, and this activity may be involved in tumor invasion."^[2]

Interactions

MMP14 has been shown to interact with TIMP2.^[3]

See also

• Matrix metalloproteinase

References

1. ^ Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M (Jul 1994). "A matrix metalloproteinase expressed on the surface of invasive tumour cells". Nature 370 (6484): 61–5. doi:10.1038/370061a0. PMID 8015608. 
2. ^ "Entrez Gene: MMP14 matrix metallopeptidase 14 (membrane-inserted)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4323. 
3. ^ Zucker, S; Drews M, Conner C, Foda H D, DeClerck Y A, Langley K E, Bahou W F, Docherty A J, Cao J (Jan. 1998). "Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)". J. Biol. Chem. (UNITED STATES) 273 (2): 1216–22. doi:10.1074/jbc.273.2.1216. ISSN 0021-9258. PMID 9422789. 

Further reading

• Nagase H, Woessner JF (1999). "Matrix metalloproteinases.". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448. 

External Links

• The MEROPS online database for peptidases and their inhibitors: M10.014