MMP9

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), also known as MMP9, is a biological enzyme.

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summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [cite web | title = Entrez Gene: MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4318| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491–4 |year= 1999 |pmid= 10419448 |doi=
*cite journal | author=Starckx S, Van den Steen PE, Wuyts A, "et al." |title=Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 233–41 |year= 2003 |pmid= 11999552 |doi=
*cite journal | author=Bischof P, Meisser A, Campana A |title=Control of MMP-9 expression at the maternal-fetal interface. |journal=J. Reprod. Immunol. |volume=55 |issue= 1-2 |pages= 3–10 |year= 2002 |pmid= 12062817 |doi=
*cite journal | author=St-Pierre Y, Van Themsche C, Estève PO |title=Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. |journal=Current drug targets. Inflammation and allergy |volume=2 |issue= 3 |pages= 206–15 |year= 2003 |pmid= 14561155 |doi=
*cite journal | author=Lee JM, Yin K, Hsin I, "et al." |title=Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. |journal=J. Neurol. Sci. |volume=229-230 |issue= |pages= 249–54 |year= 2005 |pmid= 15760647 |doi= 10.1016/j.jns.2004.11.041
*cite journal | author=Nair RR, Boyd DD |title=Expression cloning of novel regulators of 92 kDa type IV collagenase expression. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 5 |pages= 1135–6 |year= 2006 |pmid= 16246065 |doi= 10.1042/BST20051135
*cite journal | author=Ram M, Sherer Y, Shoenfeld Y |title=Matrix metalloproteinase-9 and autoimmune diseases. |journal=J. Clin. Immunol. |volume=26 |issue= 4 |pages= 299–307 |year= 2006 |pmid= 16652230 |doi= 10.1007/s10875-006-9022-6

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