TIMP2

TIMP2

TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor.

PBB_Summary
section_title =
summary_text = This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [cite web | title = Entrez Gene: TIMP2 TIMP metallopeptidase inhibitor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7077| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Liotta LA, Stetler-Stevenson W, Steeg PS |title=Metastasis suppressor genes. |journal=Important Adv. Oncol. |volume= |issue= |pages= 85–100 |year= 1991 |pmid= 1869284 |doi=
*cite journal | author=Stetler-Stevenson WG, Seo DW |title=TIMP-2: an endogenous inhibitor of angiogenesis. |journal=Trends in molecular medicine |volume=11 |issue= 3 |pages= 97–103 |year= 2005 |pmid= 15760767 |doi= 10.1016/j.molmed.2005.01.007

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Эндогенные ингибиторы металлопротеиназ — Тканевые или эндогенные ингибиторы металлопротеиназ (TIMP) семейство молекул, снижающих активность металлопротеиназ внеклеточного матрикса. У человека известно четыре эндогенных ингибитора металлопротеиназ TIMP1, TIMP2, TIMP3, TIMP4. Генетика Три …   Википедия

  • Bisphenol A — Bisphenol A IUPAC name …   Wikipedia

  • Tissue inhibitor of metalloproteinases — The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitor of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1 , TIMP2 , TIMP3 and TIMP4 . Overall, all MMPs are inhibited by TIMPs… …   Wikipedia

  • MMP14 — Matrix metallopeptidase 14 (membrane inserted) PDB rendering based on 1bqq …   Wikipedia

  • CA4 — Carbonic anhydrase IV, also known as CA4, is a human gene.cite web | title = Entrez Gene: CA4 carbonic anhydrase IV| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=762| accessdate = ] PBB Summary section… …   Wikipedia

  • Матриксная металлопротеиназа 2 — Обозначения Символы MMP2; CLG4, CLG4A HGNC …   Википедия

  • Матриксная металлопротеиназа 14 — Структура белка MMP14 …   Википедия

  • timp — TIMP, (II, V, rar IV) timpuri, s.n., (IV, înv. şi II) timpi, s.m. I. s.n. Dimensiune a Universului după care se ordonează succesiunea ireversibilă a fenomenelor. II. s.n. şi (înv.) m. 1. Durată, perioadă, măsurată în ore, zile etc., care… …   Dicționar Român

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”