CA4

CA4

Carbonic anhydrase IV, also known as CA4, is a human gene.cite web | title = Entrez Gene: CA4 carbonic anhydrase IV| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=762| accessdate = ]

PBB_Summary
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summary_text = Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.cite web | title = Entrez Gene: CA4 carbonic anhydrase IV| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=762| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Okuyama T, Sato S, Zhu XL, "et al." |title=Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1315–9 |year= 1992 |pmid= 1311094 |doi=
*cite journal | author=Hageman GS, Zhu XL, Waheed A, Sly WS |title=Localization of carbonic anhydrase IV in a specific capillary bed of the human eye. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2716–20 |year= 1991 |pmid= 1901414 |doi=
*cite journal | author=Zhu XL, Sly WS |title=Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney. |journal=J. Biol. Chem. |volume=265 |issue= 15 |pages= 8795–801 |year= 1990 |pmid= 2111324 |doi=
*cite journal | author=Carter ND, Fryer A, Grant AG, "et al." |title=Membrane specific carbonic anhydrase (CAIV) expression in human tissues. |journal=Biochim. Biophys. Acta |volume=1026 |issue= 1 |pages= 113–6 |year= 1990 |pmid= 2116168 |doi=
*cite journal | author=Whitney PL, Briggle TV |title=Membrane-associated carbonic anhydrase purified from bovine lung. |journal=J. Biol. Chem. |volume=257 |issue= 20 |pages= 12056–9 |year= 1982 |pmid= 6811592 |doi=
*cite journal | author=Bardien S, Ebenezer N, Greenberg J, "et al." |title=An eighth locus for autosomal dominant retinitis pigmentosa is linked to chromosome 17q. |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1459–62 |year= 1995 |pmid= 7581389 |doi=
*cite journal | author=Okuyama T, Waheed A, Kusumoto W, "et al." |title=Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity. |journal=Arch. Biochem. Biophys. |volume=320 |issue= 2 |pages= 315–22 |year= 1995 |pmid= 7625839 |doi=
*cite journal | author=Mahieu I, Benjamin A, Stephens R, "et al." |title=Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface of lung pulmonary endothelial cells. |journal=Biochem. Soc. Trans. |volume=23 |issue= 2 |pages= 320S |year= 1995 |pmid= 7672351 |doi=
*cite journal | author=Sender S, Gros G, Waheed A, "et al." |title=Immunohistochemical localization of carbonic anhydrase IV in capillaries of rat and human skeletal muscle. |journal=J. Histochem. Cytochem. |volume=42 |issue= 9 |pages= 1229–36 |year= 1994 |pmid= 8064130 |doi=
*cite journal | author=Okuyama T, Batanian JR, Sly WS |title=Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q. |journal=Genomics |volume=16 |issue= 3 |pages= 678–84 |year= 1993 |pmid= 8325641 |doi= 10.1006/geno.1993.1247
*cite journal | author=Fleming RE, Parkkila S, Parkkila AK, "et al." |title=Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization. |journal=J. Clin. Invest. |volume=96 |issue= 6 |pages= 2907–13 |year= 1996 |pmid= 8675662 |doi=
*cite journal | author=Waheed A, Okuyama T, Heyduk T, Sly WS |title=Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds. |journal=Arch. Biochem. Biophys. |volume=333 |issue= 2 |pages= 432–8 |year= 1996 |pmid= 8809084 |doi= 10.1006/abbi.1996.0412
*cite journal | author=Parkkila S, Parkkila AK, Juvonen T, "et al." |title=Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium. |journal=Hepatology |volume=24 |issue= 5 |pages= 1104–8 |year= 1996 |pmid= 8903383 |doi= 10.1002/hep.510240521
*cite journal | author=Stams T, Nair SK, Okuyama T, "et al." |title=Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13589–94 |year= 1997 |pmid= 8942978 |doi=
*cite journal | author=Bardien S, Ramesar R, Bhattacharya S, Greenberg J |title=Retinitis pigmentosa locus on 17q (RP17): fine localization to 17q22 and exclusion of the PDEG and TIMP2 genes. |journal=Hum. Genet. |volume=101 |issue= 1 |pages= 13–7 |year= 1997 |pmid= 9385361 |doi=
*cite journal | author=Sender S, Decker B, Fenske CD, "et al." |title=Localization of carbonic anhydrase IV in rat and human heart muscle. |journal=J. Histochem. Cytochem. |volume=46 |issue= 7 |pages= 855–61 |year= 1998 |pmid= 9632745 |doi=
*cite journal | author=Wistrand PJ, Carter ND, Conroy CW, Mahieu I |title=Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes. |journal=Acta Physiol. Scand. |volume=165 |issue= 2 |pages= 211–8 |year= 1999 |pmid= 10090333 |doi=
*cite journal | author=Fujikawa-Adachi K, Nishimori I, Sakamoto S, "et al." |title=Identification of carbonic anhydrase IV and VI mRNA expression in human pancreas and salivary glands. |journal=Pancreas |volume=18 |issue= 4 |pages= 329–35 |year= 1999 |pmid= 10231836 |doi=
*cite journal | author=Sterling D, Alvarez BV, Casey JR |title=The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25239–46 |year= 2002 |pmid= 11994299 |doi= 10.1074/jbc.M202562200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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