- ADAM9
ADAM metallopeptidase domain 9 (meltrin gamma), also known as ADAM9, is a human
gene .cite web | title = Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8754| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.cite web | title = Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8754| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=
*cite journal | author=Weskamp G, Krätzschmar J, Reid MS, Blobel CP |title=MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. |journal=J. Cell Biol. |volume=132 |issue= 4 |pages= 717–26 |year= 1996 |pmid= 8647900 |doi=
*cite journal | author=McKie N, Dallas DJ, Edwards T, "et al." |title=Cloning of a novel membrane-linked metalloproteinase from human myeloma cells. |journal=Biochem. J. |volume=318 ( Pt 2) |issue= |pages= 459–62 |year= 1996 |pmid= 8809033 |doi=
*cite journal | author=McKie N, Edwards T, Dallas DJ, "et al." |title=Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. |journal=Biochem. Biophys. Res. Commun. |volume=230 |issue= 2 |pages= 335–9 |year= 1997 |pmid= 9016778 |doi= 10.1006/bbrc.1996.5957
*cite journal | author=Izumi Y, Hirata M, Hasuwa H, "et al." |title=A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7260–72 |year= 1999 |pmid= 9857183 |doi= 10.1093/emboj/17.24.7260
*cite journal | author=Roghani M, Becherer JD, Moss ML, "et al." |title=Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3531–40 |year= 1999 |pmid= 9920899 |doi=
*cite journal | author=Nelson KK, Schlöndorff J, Blobel CP |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages= 673–80 |year= 2000 |pmid= 10527948 |doi=
*cite journal | author=Howard L, Nelson KK, Maciewicz RA, Blobel CP |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31693–9 |year= 1999 |pmid= 10531379 |doi=
*cite journal | author=Zhou M, Graham R, Russell G, Croucher PI |title=MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 2 |pages= 574–80 |year= 2001 |pmid= 11162558 |doi= 10.1006/bbrc.2000.4155
*cite journal | author=Namba K, Nishio M, Mori K, "et al." |title=Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes. |journal=Cell. Immunol. |volume=213 |issue= 2 |pages= 104–13 |year= 2002 |pmid= 11831872 |doi= 10.1006/cimm.2001.1873
*cite journal | author=Eto K, Huet C, Tarui T, "et al." |title=Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17804–10 |year= 2002 |pmid= 11882657 |doi= 10.1074/jbc.M200086200
*cite journal | author=Lim JM, Lee JH, Wee WR, Joo CK |title=Downregulated expression of ADAM9 in anterior polar cataracts. |journal=Journal of cataract and refractive surgery |volume=28 |issue= 4 |pages= 697–702 |year= 2002 |pmid= 11955914 |doi=
*cite journal | author=Hotoda N, Koike H, Sasagawa N, Ishiura S |title=A secreted form of human ADAM9 has an alpha-secretase activity for APP. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 2 |pages= 800–5 |year= 2002 |pmid= 12054541 |doi= 10.1016/S0006-291X(02)00302-9
*cite journal | author=Amour A, Knight CG, English WR, "et al." |title=The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 154–8 |year= 2002 |pmid= 12135759 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mohan S, Thompson GR, Amaar YG, "et al." |title=ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. |journal=Biochemistry |volume=41 |issue= 51 |pages= 15394–403 |year= 2003 |pmid= 12484779 |doi=
*cite journal | author=Asai M, Hattori C, Szabó B, "et al." |title=Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 231–5 |year= 2003 |pmid= 12535668 |doi=
*cite journal | author=O'Shea C, McKie N, Buggy Y, "et al." |title=Expression of ADAM-9 mRNA and protein in human breast cancer. |journal=Int. J. Cancer |volume=105 |issue= 6 |pages= 754–61 |year= 2003 |pmid= 12767059 |doi= 10.1002/ijc.11161
*cite journal | author=Grützmann R, Lüttges J, Sipos B, "et al." |title=ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. |journal=Br. J. Cancer |volume=90 |issue= 5 |pages= 1053–8 |year= 2004 |pmid= 14997207 |doi= 10.1038/sj.bjc.6601645PBB_Controls
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