PEA15

PEA15
Phosphoprotein enriched in astrocytes 15

PDB rendering based on 1n3k.
Identifiers
Symbols PEA15; HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED
External IDs OMIM603434 MGI104799 HomoloGene7884 GeneCards: PEA15 Gene
RNA expression pattern
PBB GE PEA15 200788 s at tn.png
PBB GE PEA15 200787 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8682 18611
Ensembl ENSG00000162734 ENSMUSG00000013698
UniProt Q15121 Q62048
RefSeq (mRNA) NM_003768 NM_011063.2
RefSeq (protein) NP_003759 NP_035193.1
Location (UCSC) Chr 1:
160.18 – 160.19 Mb
Chr 1:
174.13 – 174.14 Mb
PubMed search [1] [2]

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.[1][2]

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[2]

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.[3]


Interactions

PEA15 has been shown to interact with Phospholipase D1,[4] Caspase 8,[5][6] MAPK1,[7] FADD[5][6] and RPS6KA3.[8]

References

  1. ^ Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (Sep 1997). "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers". Genomics 42 (3): 540–2. doi:10.1006/geno.1997.4768. PMID 9205133. 
  2. ^ a b "Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8682. 
  3. ^ Böck BC, Tagscherer KE, Fassl A, et al. (July 2010). "The PEA-15 protein regulates autophagy via activation of JNK". J. Biol. Chem. 285 (28): 21644–54. doi:10.1074/jbc.M109.096628. PMC 2898427. PMID 20452983. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=20452983. 
  4. ^ Zhang, Y; Redina O, Altshuller Y M, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman M A (Nov. 2000). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. (UNITED STATES) 275 (45): 35224–32. doi:10.1074/jbc.M003329200. ISSN 0021-9258. PMID 10926929. 
  5. ^ a b Kitsberg, D; Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H (Oct. 1999). "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. Neurosci. (UNITED STATES) 19 (19): 8244–51. PMID 10493725. 
  6. ^ a b Condorelli, G; Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (Aug. 1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis". Oncogene (ENGLAND) 18 (31): 4409–15. doi:10.1038/sj.onc.1202831. ISSN 0950-9232. PMID 10442631. 
  7. ^ Formstecher, E; Ramos J W, Fauquet M, Calderwood D A, Hsieh J C, Canton B, Nguyen X T, Barnier J V, Camonis J, Ginsberg M H, Chneiweiss H (Aug. 2001). "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell (United States) 1 (2): 239–50. doi:10.1016/S1534-5807(01)00035-1. ISSN 1534-5807. PMID 11702783. 
  8. ^ Vaidyanathan, Hema; Ramos Joe W (Aug. 2003). "RSK2 activity is regulated by its interaction with PEA-15". J. Biol. Chem. (United States) 278 (34): 32367–72. doi:10.1074/jbc.M303988200. ISSN 0021-9258. PMID 12796492. 

Further reading


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Look at other dictionaries:

  • PEA15 — Fosfoproteína astrocítica 15 Estructura tridimensional de la proteína PEA15. HUGO …   Wikipedia Español

  • MAPK1 — Mitogen activated protein kinase 1 PDB rendering based on 1erk …   Wikipedia

  • Phospholipase D1 — Phospholipase D1, phosphatidylcholine specific Identifiers Symbols PLD1; External IDs …   Wikipedia

  • MAPK1 — MAP quinasa 1 Estructura tridimensional de la proteína MAPK1. HUGO 6871 …   Wikipedia Español

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