Caspase 8

Caspase 8

Caspase 8 is a caspase protein. It most likely acts upon caspase 3.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [cite web | title = Entrez Gene: CASP8 caspase 8, apoptosis-related cysteine peptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=841| accessdate = ]

References

Further reading

*cite journal | author=Song, HJ, Parodo, J, Kapus, A, Rotstein, OD, and Marshall, JC |title=Dynamic Regulation of Neutrophil Survival through Tyrosine Phosphorylation or Dephosphorylation of Caspase-8 |journal=Journal of Biological Chemistry |volume=283 |issue= |pages= 5402–5413 |year= 2008 |pmid= |doi= PBB_Further_reading
citations =
*cite journal | author=Cohen GM |title=Caspases: the executioners of apoptosis |journal=Biochem. J. |volume=326 ( Pt 1) |issue= |pages= 1–16 |year= 1997 |pmid= 9337844 |doi=
*cite journal | author=Siegel RM, Chan FK, Chun HJ, Lenardo MJ |title=The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity |journal=Nat. Immunol. |volume=1 |issue= 6 |pages= 469–74 |year= 2001 |pmid= 11101867 |doi= 10.1038/82712
*cite journal | author=Ye S, Goldsmith EJ |title=Serpins and other covalent protease inhibitors |journal=Curr. Opin. Struct. Biol. |volume=11 |issue= 6 |pages= 740–5 |year= 2002 |pmid= 11751056 |doi=
*cite journal | author=Gupta S |title=Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules |journal=Exp. Gerontol. |volume=37 |issue= 2-3 |pages= 293–9 |year= 2002 |pmid= 11772515 |doi=
*cite journal | author=Pomerantz RJ |title=Effects of HIV-1 Vpr on neuroinvasion and neuropathogenesis |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 227–38 |year= 2004 |pmid= 15142380 |doi= 10.1089/104454904773819815
*cite journal | author=Zhao LJ, Zhu H |title=Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design |journal=Curr. Drug Targets Immune Endocr. Metabol. Disord. |volume=4 |issue= 4 |pages= 265–75 |year= 2005 |pmid= 15578977 |doi=

ee also

* FADD

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Caspase-9 — Caspase 9, apoptosis related cysteine peptidase PDB rendering based on 1jxq …   Wikipedia

  • Caspase 2 — is an enzyme that proteolytically cleaves other proteins.It belongs to a family of cysteine proteases called caspases that only cleave proteins at an amino acid following a aspartic acid residue. Within this family, caspase 2 is part of the Ich 1 …   Wikipedia

  • Caspase 10 — Caspase 10, apoptosis related cysteine peptidase, also known as CASP10, is a human gene. PBB Summary section title = summary text = This gene encodes a protein which is a member of the cysteine aspartic acid protease (caspase) family. Sequential… …   Wikipedia

  • Caspase 7 — Caspase 7, apoptosis related cysteine peptidase, also known as CASP7, is a human protein and gene. PBB Summary section title = summary text = Caspase 7 is a member of the caspase (cysteine aspartate protase) family of proteins, and has been shown …   Wikipedia

  • Caspase 6 — Caspase 6, apoptosis related cysteine peptidase, also known as CASP6, is a human gene. PBB Summary section title = summary text = This gene encodes a protein which is a member of the cysteine aspartic acid protease (caspase) family. Sequential… …   Wikipedia

  • Caspase 13 — is an enzyme known as a cysteine protease that was identified in cattle that is also called Evolutionarily Related Interleukin 1β Converting Enzyme (ERICE). It belongs to a family of enzymes called caspases that cleave their substrates at C… …   Wikipedia

  • Caspase 1 — is an enzyme that proteolytically cleaves other proteins, such as the precursor forms of the inflammatory cytokines interleukin 1 β and interleukin 18, into active mature peptides. [cite journal |author=Thornberry N, Bull H, Calaycay J, Chapman K …   Wikipedia

  • Caspase 3 — is a caspase protein. It interacts with caspase 8. PBB Summary section title = summary text = This gene encodes a protein that is a member of the cysteine aspartic acid protease (caspase) family. Sequential activation of caspases plays a central… …   Wikipedia

  • Caspase — Caspases, or c ysteine asp artic acid prote ases , are a family of cysteine proteases, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Caspases are essential in cells for apoptosis, one of the main… …   Wikipedia

  • Caspase 12 — protein Name = caspase 12 caption = width = 240px HGNCid = 19004 Symbol = CASP12 AltSymbols = CASP12P1 EntrezGene = 120329 OMIM = 608633 RefSeq = NR 000035 UniProt = Q6UXS9 PDB = ECnumber = Chromosome = 11 Arm = q Band = 22.3… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”