- FADD
Fas-Associated protein with Death Domain (FADD) is an adaptor molecule that bridges the Fas-receptor, and other death receptors, to
caspase-8 through its "death domain" to form thedeath inducing signaling complex (DISC) duringapoptosis . PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor,tumor necrosis factor receptor , TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain [cite journal|author= Eberstadt M, "et al."|title= NMR structure and mutagenesis of the FADD (Mort1) death-effector domain|year=1998|journal=Nature|volume=391|pages=941–5|url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9582077|doi= 10.1038/31972] (see structural image on the right side) of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [cite web | title = Entrez Gene: FADD Fas (TNFRSF6)-associated via death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8772| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Sheikh MS, Huang Y |title=The FADD is going nuclear. |journal=Cell Cycle |volume=2 |issue= 4 |pages= 346–7 |year= 2004 |pmid= 12851487 |doi=
*cite journal | author=Bhojani MS, Chen G, Ross BD, "et al." |title=Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. |journal=Cell Cycle |volume=4 |issue= 11 |pages= 1478–81 |year= 2007 |pmid= 16258269 |doi=ee also
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TRADD External links
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PBB_Controls
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