MMP26

Matrix metallopeptidase 26, also known as MMP26, is a human gene.cite web | title = Entrez Gene: MMP26 matrix metallopeptidase 26| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56547| accessdate = ]

PBB_Summary
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summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.cite web | title = Entrez Gene: MMP26 matrix metallopeptidase 26| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56547| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491–4 |year= 1999 |pmid= 10419448 |doi=
*cite journal | author=Park HI, Ni J, Gerkema FE, "et al." |title=Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20540–4 |year= 2000 |pmid= 10801841 |doi= 10.1074/jbc.M002349200
*cite journal | author=de Coignac AB, Elson G, Delneste Y, "et al." |title=Cloning of MMP-26. A novel matrilysin-like proteinase. |journal=Eur. J. Biochem. |volume=267 |issue= 11 |pages= 3323–9 |year= 2000 |pmid= 10824119 |doi=
*cite journal | author=Uría JA, López-Otín C |title=Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. |journal=Cancer Res. |volume=60 |issue= 17 |pages= 4745–51 |year= 2000 |pmid= 10987280 |doi=
*cite journal | author=Marchenko GN, Ratnikov BI, Rozanov DV, "et al." |title=Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin. |journal=Biochem. J. |volume=356 |issue= Pt 3 |pages= 705–18 |year= 2001 |pmid= 11389678 |doi=
*cite journal | author=Gearing AJ, Thorpe SJ, Miller K, "et al." |title=Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin. |journal=Immunol. Lett. |volume=81 |issue= 1 |pages= 41–8 |year= 2002 |pmid= 11841844 |doi=
*cite journal | author=Marchenko ND, Marchenko GN, Strongin AY |title=Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18967–72 |year= 2002 |pmid= 11889136 |doi= 10.1074/jbc.M201197200
*cite journal | author=Marchenko GN, Marchenko ND, Leng J, Strongin AY |title=Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. |journal=Biochem. J. |volume=363 |issue= Pt 2 |pages= 253–62 |year= 2002 |pmid= 11931652 |doi=
*cite journal | author=Park HI, Turk BE, Gerkema FE, "et al." |title=Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35168–75 |year= 2002 |pmid= 12119297 |doi= 10.1074/jbc.M205071200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhao YG, Xiao AZ, Newcomer RG, "et al." |title=Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15056–64 |year= 2003 |pmid= 12586837 |doi= 10.1074/jbc.M210975200
*cite journal | author=Chegini N, Rhoton-Vlasak A, Williams RS |title=Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding. |journal=Fertil. Steril. |volume=80 |issue= 3 |pages= 564–70 |year= 2003 |pmid= 12969699 |doi=
*cite journal | author=Park HI, Jin Y, Hurst DR, "et al." |title=The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51646–53 |year= 2004 |pmid= 14532275 |doi= 10.1074/jbc.M310109200
*cite journal | author=Zhao YG, Xiao AZ, Park HI, "et al." |title=Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 590–8 |year= 2004 |pmid= 14744773 |doi=
*cite journal | author=Pilka R, Domanski H, Hansson S, "et al." |title=Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26. |journal=Mol. Hum. Reprod. |volume=10 |issue= 9 |pages= 641–50 |year= 2005 |pmid= 15273280 |doi= 10.1093/molehr/gah092
*cite journal | author=Yamamoto H, Vinitketkumnuen A, Adachi Y, "et al." |title=Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma. |journal=Carcinogenesis |volume=25 |issue= 12 |pages= 2353–60 |year= 2005 |pmid= 15333466 |doi= 10.1093/carcin/bgh270
*cite journal | author=Pilka R, Norata GD, Domanski H, "et al." |title=Matrix metalloproteinase-26 (matrilysin-2) expression is high in endometrial hyperplasia and decreases with loss of histological differentiation in endometrial cancer. |journal=Gynecol. Oncol. |volume=94 |issue= 3 |pages= 661–70 |year= 2004 |pmid= 15350356 |doi= 10.1016/j.ygyno.2004.05.024
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Li W, Savinov AY, Rozanov DV, "et al." |title=Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin. |journal=Cancer Res. |volume=64 |issue= 23 |pages= 8657–65 |year= 2005 |pmid= 15574774 |doi= 10.1158/0008-5472.CAN-04-3019

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