Bone morphogenetic protein 1

Bone morphogenetic protein 1 (BMP1) is a protein that belongs to the peptidase M12A family of proteins. It induces bone and cartilage development. It is unlike other bone morphogenetic proteins since it does not belong to the TGFβ superfamily of proteins. It was initially discovered to work like other bone morphogenetic proteins by inducing bone and cartilage development. It however, is a metalloprotease that cleaves the C-terminus of procollagen I, II and III. It has an astacin-like protease domain.

It has been shown to cleave laminin 5 and is localized in the basal epithelial layer of bovine skin.

There are seven isoforms of the enzyme created by alternate splicing.

Bone morphogenetic protein 1, also known as BMP1, is a human gene.cite web | title = Entrez Gene: BMP1 bone morphogenetic protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=649| accessdate = ]

PBB_Summary
section_title =
summary_text = The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal regioncite web | title = Entrez Gene: BMP1 bone morphogenetic protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=649| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tabas JA, Zasloff M, Wasmuth JJ, "et al." |title=Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. |journal=Genomics |volume=9 |issue= 2 |pages= 283–9 |year= 1991 |pmid= 2004778 |doi=
*cite journal | author=Wozney JM, Rosen V, Celeste AJ, "et al." |title=Novel regulators of bone formation: molecular clones and activities. |journal=Science |volume=242 |issue= 4885 |pages= 1528–34 |year= 1989 |pmid= 3201241 |doi=
*cite journal | author=Takahara K, Lyons GE, Greenspan DS |title=Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32572–8 |year= 1995 |pmid= 7798260 |doi=
*cite journal | author=Yoshiura K, Tamura T, Hong HS, "et al." |title=Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome. |journal=Cytogenet. Cell Genet. |volume=64 |issue= 3-4 |pages= 208–9 |year= 1993 |pmid= 8404039 |doi=
*cite journal | author=Takahara K, Lee S, Wood S, Greenspan DS |title=Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene. |journal=Genomics |volume=29 |issue= 1 |pages= 9–15 |year= 1996 |pmid= 8530106 |doi= 10.1006/geno.1995.1209
*cite journal | author=Kessler E, Takahara K, Biniaminov L, "et al." |title=Bone morphogenetic protein-1: the type I procollagen C-proteinase. |journal=Science |volume=271 |issue= 5247 |pages= 360–2 |year= 1996 |pmid= 8553073 |doi=
*cite journal | author=Li SW, Sieron AL, Fertala A, "et al." |title=The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 5127–30 |year= 1996 |pmid= 8643539 |doi=
*cite journal | author=Janitz M, Heiser V, Böttcher U, "et al." |title=Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1. |journal=J. Mol. Med. |volume=76 |issue= 2 |pages= 141–6 |year= 1998 |pmid= 9500680 |doi=
*cite journal | author=Scott IC, Blitz IL, Pappano WN, "et al." |title=Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. |journal=Dev. Biol. |volume=213 |issue= 2 |pages= 283–300 |year= 1999 |pmid= 10479448 |doi= 10.1006/dbio.1999.9383
*cite journal | author=Amano S, Scott IC, Takahara K, "et al." |title=Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22728–35 |year= 2000 |pmid= 10806203 |doi= 10.1074/jbc.M002345200
*cite journal | author=Scott IC, Blitz IL, Pappano WN, "et al." |title=Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. |journal=Nature |volume=410 |issue= 6827 |pages= 475–8 |year= 2001 |pmid= 11260715 |doi= 10.1038/35068572
*cite journal | author=Garrigue-Antar L, Barker C, Kadler KE |title=Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26237–42 |year= 2001 |pmid= 11283002 |doi= 10.1074/jbc.M010814200
*cite journal | author=Unsöld C, Pappano WN, Imamura Y, "et al." |title=Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5596–602 |year= 2002 |pmid= 11741999 |doi= 10.1074/jbc.M110003200
*cite journal | author=Rattenholl A, Pappano WN, Koch M, "et al." |title=Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26372–8 |year= 2002 |pmid= 11986329 |doi= 10.1074/jbc.M203247200
*cite journal | author=Garrigue-Antar L, Hartigan N, Kadler KE |title=Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43327–34 |year= 2003 |pmid= 12218058 |doi= 10.1074/jbc.M207342200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hartigan N, Garrigue-Antar L, Kadler KE |title=Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18045–9 |year= 2003 |pmid= 12637537 |doi= 10.1074/jbc.M211448200
*cite journal | author=Leighton M, Kadler KE |title=Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18478–84 |year= 2003 |pmid= 12637569 |doi= 10.1074/jbc.M213021200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8

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