Bone morphogenetic protein 8b

Bone morphogenetic protein 8b (osteogenic protein 2), also known as BMP8B, is a human gene.cite web | title = Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=656| accessdate = ]

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.cite web | title = Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=656| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Wen XZ, Akiyama Y, Baylin SB, Yuasa Y |title=Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. |journal=Oncogene |volume=25 |issue= 18 |pages= 2666-73 |year= 2006 |pmid= 16314833 |doi= 10.1038/sj.onc.1209297
*cite journal | author=Saito T, Ji G, Shinzawa H, "et al." |title=Genetic variations in humans associated with differences in the course of hepatitis C. |journal=Biochem. Biophys. Res. Commun. |volume=317 |issue= 2 |pages= 335-41 |year= 2004 |pmid= 15063762 |doi= 10.1016/j.bbrc.2004.03.056
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ying Y, Qi X, Zhao GQ |title=Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 14 |pages= 7858-62 |year= 2001 |pmid= 11427739 |doi= 10.1073/pnas.151242798
*cite journal | author=Ying Y, Liu XM, Marble A, "et al." |title=Requirement of Bmp8b for the generation of primordial germ cells in the mouse. |journal=Mol. Endocrinol. |volume=14 |issue= 7 |pages= 1053-63 |year= 2000 |pmid= 10894154 |doi=
*cite journal | author=DiLeone RJ, King JA, Storm EE, "et al." |title=The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. |journal=Genomics |volume=40 |issue= 1 |pages= 196-8 |year= 1997 |pmid= 9070944 |doi= 10.1006/geno.1996.4533
*cite journal | author=Auffray C, Behar G, Bois F, "et al." |title= [

*cite journal | author=Ozkaynak E, Schnegelsberg PN, Jin DF, "et al." |title=Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. |journal=J. Biol. Chem. |volume=267 |issue= 35 |pages= 25220-7 |year= 1993 |pmid= 1460021 |doi=

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