Bone morphogenetic protein 6

Bone morphogenetic protein 6, also known as BMP6, is a human gene.cite web | title = Entrez Gene: BMP6 bone morphogenetic protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=654| accessdate = ]

The protein encoded by this gene is a a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.cite web | title = Entrez Gene: BMP6 bone morphogenetic protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=654| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hahn GV, Cohen RB, Wozney JM, "et al." |title=A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. |journal=Genomics |volume=14 |issue= 3 |pages= 759–62 |year= 1992 |pmid= 1427904 |doi=
*cite journal | author=Sauermann U, Meyermann R, Schluesener HJ |title=Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines. |journal=J. Neurosci. Res. |volume=33 |issue= 1 |pages= 142–7 |year= 1993 |pmid= 1453478 |doi= 10.1002/jnr.490330118
*cite journal | author=Celeste AJ, Iannazzi JA, Taylor RC, "et al." |title=Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9843–7 |year= 1991 |pmid= 2263636 |doi=
*cite journal | author=Schluesener HJ, Meyermann R |title=Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells. |journal=Atherosclerosis |volume=113 |issue= 2 |pages= 153–6 |year= 1995 |pmid= 7605353 |doi=
*cite journal | author=Gitelman SE, Kobrin MS, Ye JQ, "et al." |title=Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. |journal=J. Cell Biol. |volume=126 |issue= 6 |pages= 1595–609 |year= 1994 |pmid= 8089189 |doi=
*cite journal | author=Barnes J, Anthony CT, Wall N, Steiner MS |title=Bone morphogenetic protein-6 expression in normal and malignant prostate. |journal=World journal of urology |volume=13 |issue= 6 |pages= 337–43 |year= 1997 |pmid= 9116752 |doi=
*cite journal | author=Hamdy FC, Autzen P, Robinson MC, "et al." |title=Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue. |journal=Cancer Res. |volume=57 |issue= 19 |pages= 4427–31 |year= 1997 |pmid= 9331107 |doi=
*cite journal | author=Olavesen MG, Bentley E, Mason RV, "et al." |title=Fine mapping of 39 ESTs on human chromosome 6p23-p25. |journal=Genomics |volume=46 |issue= 2 |pages= 303–6 |year= 1998 |pmid= 9417921 |doi= 10.1006/geno.1997.5032
*cite journal | author=Rickard DJ, Hofbauer LC, Bonde SK, "et al." |title=Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen. |journal=J. Clin. Invest. |volume=101 |issue= 2 |pages= 413–22 |year= 1998 |pmid= 9435314 |doi=
*cite journal | author=Tamada H, Kitazawa R, Gohji K, "et al." |title=Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6). |journal=Biochim. Biophys. Acta |volume=1395 |issue= 3 |pages= 247–51 |year= 1998 |pmid= 9512655 |doi=
*cite journal | author=Ebisawa T, Tada K, Kitajima I, "et al." |title=Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. |journal=J. Cell. Sci. |volume=112 ( Pt 20) |issue= |pages= 3519–27 |year= 2000 |pmid= 10504300 |doi=
*cite journal | author=Heikinheimo KA, Laine MA, Ritvos OV, "et al." |title=Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. |journal=Cancer Res. |volume=59 |issue= 22 |pages= 5815–21 |year= 1999 |pmid= 10582704 |doi=
*cite journal | author=Ahmed N, Sammons J, Carson RJ, "et al." |title=Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma. |journal=Cell Biol. Int. |volume=25 |issue= 5 |pages= 429–35 |year= 2001 |pmid= 11401330 |doi= 10.1006/cbir.2000.0662
*cite journal | author=Shimizu M, Higuchi K, Kasai S, "et al." |title=A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density. |journal=Mamm. Genome |volume=13 |issue= 7 |pages= 335–40 |year= 2003 |pmid= 12140680 |doi= 10.1007/s00335-001-2129-4
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Moser M, Binder O, Wu Y, "et al." |title=BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5664–79 |year= 2003 |pmid= 12897139 |doi=
*cite journal | author=Bobacz K, Gruber R, Soleiman A, "et al." |title=Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. |journal=Arthritis Rheum. |volume=48 |issue= 9 |pages= 2501–8 |year= 2003 |pmid= 13130469 |doi= 10.1002/art.11248
*cite journal | author=Lories RJ, Derese I, Ceuppens JL, Luyten FP |title=Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. |journal=Arthritis Rheum. |volume=48 |issue= 10 |pages= 2807–18 |year= 2003 |pmid= 14558086 |doi= 10.1002/art.11389
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Laurikkala J, Kassai Y, Pakkasjärvi L, "et al." |title=Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. |journal=Dev. Biol. |volume=264 |issue= 1 |pages= 91–105 |year= 2004 |pmid= 14623234 |doi=

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