MMP11

Matrix metallopeptidase 11 (stromelysin 3), also known as MMP11, is a human gene.cite web | title = Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4320| accessdate = ]

PBB_Summary
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summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.cite web | title = Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4320| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491–4 |year= 1999 |pmid= 10419448 |doi=
*cite journal | author=Levy A, Zucman J, Delattre O, "et al." |title=Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. |journal=Genomics |volume=13 |issue= 3 |pages= 881–3 |year= 1992 |pmid= 1639418 |doi=
*cite journal | author=Basset P, Bellocq JP, Wolf C, "et al." |title=A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. |journal=Nature |volume=348 |issue= 6303 |pages= 699–704 |year= 1991 |pmid= 1701851 |doi= 10.1038/348699a0
*cite journal | author=Pei D, Majmudar G, Weiss SJ |title=Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3. |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25849–55 |year= 1994 |pmid= 7523394 |doi=
*cite journal | author=Anglard P, Melot T, Guérin E, "et al." |title=Structure and promoter characterization of the human stromelysin-3 gene. |journal=J. Biol. Chem. |volume=270 |issue= 35 |pages= 20337–44 |year= 1995 |pmid= 7657606 |doi=
*cite journal | author=Pei D, Weiss SJ |title=Furin-dependent intracellular activation of the human stromelysin-3 zymogen. |journal=Nature |volume=375 |issue= 6528 |pages= 244–7 |year= 1995 |pmid= 7746327 |doi= 10.1038/375244a0
*cite journal | author=Boulay A, Masson R, Chenard MP, "et al." |title=High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2189–93 |year= 2001 |pmid= 11280785 |doi=
*cite journal | author=Perret AG, Duthel R, Fotso MJ, "et al." |title=Stromelysin-3 is expressed by aggressive meningiomas. |journal=Cancer |volume=94 |issue= 3 |pages= 765–72 |year= 2002 |pmid= 11857311 |doi=
*cite journal | author=Luo D, Mari B, Stoll I, Anglard P |title=Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25527–36 |year= 2002 |pmid= 12006591 |doi= 10.1074/jbc.M202494200
*cite journal | author=Nakopoulou L, Panayotopoulou EG, Giannopoulou I, "et al." |title=Stromelysin-3 protein expression in invasive breast cancer: relation to proliferation, cell survival and patients' outcome. |journal=Mod. Pathol. |volume=15 |issue= 11 |pages= 1154–61 |year= 2003 |pmid= 12429794 |doi= 10.1097/01.MP.0000037317.84782.CD
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wasenius VM, Hemmer S, Kettunen E, "et al." |title=Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study. |journal=Clin. Cancer Res. |volume=9 |issue= 1 |pages= 68–75 |year= 2003 |pmid= 12538453 |doi=
*cite journal | author=Fromigué O, Louis K, Wu E, "et al." |title=Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase. |journal=Int. J. Cancer |volume=106 |issue= 3 |pages= 355–63 |year= 2003 |pmid= 12845673 |doi= 10.1002/ijc.11232
*cite journal | author=Skoglund J, Emterling A, Arbman G, "et al." |title=Clinicopathological significance of stromelysin-3 expression in colorectal cancer. |journal=Oncology |volume=67 |issue= 1 |pages= 67–72 |year= 2004 |pmid= 15459498 |doi= 10.1159/000080288
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Louis K, Guérineau N, Fromigué O, "et al." |title=Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1272–83 |year= 2005 |pmid= 15509588 |doi= 10.1074/jbc.M405482200
*cite journal | author=Deng H, Guo RF, Li WM, "et al." |title=Matrix metalloproteinase 11 depletion inhibits cell proliferation in gastric cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=326 |issue= 2 |pages= 274–81 |year= 2005 |pmid= 15582574 |doi= 10.1016/j.bbrc.2004.11.027
*cite journal | author=Arora S, Kaur J, Sharma C, "et al." |title=Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis. |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2272–84 |year= 2005 |pmid= 15788677 |doi= 10.1158/1078-0432.CCR-04-0572
*cite journal | author=Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, "et al." |title=Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. |journal=BMC Cancer |volume=5 |issue= 1 |pages= 68 |year= 2006 |pmid= 15989693 |doi= 10.1186/1471-2407-5-68

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