ADAM33

ADAM metallopeptidase domain 33, also known as ADAM33, is a human gene.cite web | title = Entrez Gene: ADAM33 ADAM metallopeptidase domain 33| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80332| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: ADAM33 ADAM metallopeptidase domain 33| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80332| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Holgate ST, Davies DE, Rorke S, "et al." |title=ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma. |journal=Clinical reviews in allergy & immunology |volume=27 |issue= 1 |pages= 23–34 |year= 2005 |pmid= 15347848 |doi=
*cite journal | author=Holloway JW, Davies DE, Powell R, "et al." |title=The discovery and role of ADAM33, a new candidate gene for asthma. |journal=Expert reviews in molecular medicine |volume=6 |issue= 17 |pages= 1–12 |year= 2007 |pmid= 15387895 |doi= 10.1017/S1462399404007963
*cite journal | author=Holgate ST, Yang Y, Haitchi HM, "et al." |title=The genetics of asthma: ADAM33 as an example of a susceptibility gene. |journal=Proceedings of the American Thoracic Society |volume=3 |issue= 5 |pages= 440–3 |year= 2006 |pmid= 16799089 |doi= 10.1513/pats.200603-026AW
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Yoshinaka T, Nishii K, Yamada K, "et al." |title=Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. |journal=Gene |volume=282 |issue= 1-2 |pages= 227–36 |year= 2002 |pmid= 11814695 |doi=
*cite journal | author=Van Eerdewegh P, Little RD, Dupuis J, "et al." |title=Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. |journal=Nature |volume=418 |issue= 6896 |pages= 426–30 |year= 2002 |pmid= 12110844 |doi= 10.1038/nature00878
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Garlisi CG, Zou J, Devito KE, "et al." |title=Human ADAM33: protein maturation and localization. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 35–43 |year= 2003 |pmid= 12535637 |doi=
*cite journal | author=Chae SC, Yoon KH, Chung HT |title=Identification of novel polymorphisms in the Adam33 gene. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 278–81 |year= 2003 |pmid= 12768445 |doi= 10.1007/s10038-003-0019-1
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Howard TD, Postma DS, Jongepier H, "et al." |title=Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. |journal=J. Allergy Clin. Immunol. |volume=112 |issue= 4 |pages= 717–22 |year= 2003 |pmid= 14564349 |doi= 10.1016/S0091
*cite journal | author=Orth P, Reichert P, Wang W, "et al." |title=Crystal structure of the catalytic domain of human ADAM33. |journal=J. Mol. Biol. |volume=335 |issue= 1 |pages= 129–37 |year= 2004 |pmid= 14659745 |doi=
*cite journal | author=Zou J, Zhu F, Liu J, "et al." |title=Catalytic activity of human ADAM33. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 9818–30 |year= 2004 |pmid= 14676211 |doi= 10.1074/jbc.M309696200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Powell RM, Wicks J, Holloway JW, "et al." |title=The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts. |journal=Am. J. Respir. Cell Mol. Biol. |volume=31 |issue= 1 |pages= 13–21 |year= 2004 |pmid= 14742294 |doi= 10.1165/rcmb.2003-0330OC
*cite journal | author=Haitchi HM, Powell RM, Shaw TJ, "et al." |title=ADAM33 expression in asthmatic airways and human embryonic lungs. |journal=Am. J. Respir. Crit. Care Med. |volume=171 |issue= 9 |pages= 958–65 |year= 2005 |pmid= 15709049 |doi= 10.1164/rccm.200409-1251OC
*cite journal | author=Zou J, Zhang R, Zhu F, "et al." |title=ADAM33 enzyme properties and substrate specificity. |journal=Biochemistry |volume=44 |issue= 11 |pages= 4247–56 |year= 2005 |pmid= 15766253 |doi= 10.1021/bi0476230
*cite journal | author=Simpson A, Maniatis N, Jury F, "et al." |title=Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. |journal=Am. J. Respir. Crit. Care Med. |volume=172 |issue= 1 |pages= 55–60 |year= 2005 |pmid= 15805180 |doi= 10.1164/rccm.200412-1708OC

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