GSTP1

GSTP1

Glutathione S-transferase pi, also known as GSTP1, is a human gene.

PBB_Summary
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summary_text = Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [cite web | title = Entrez Gene: GSTP1 glutathione S-transferase pi| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2950| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Strange RC, Fryer AA |title=The glutathione S-transferases: influence of polymorphism on cancer susceptibility. |journal=IARC Sci. Publ. |volume= |issue= 148 |pages= 231–49 |year= 1999 |pmid= 10493261 |doi=
*cite journal | author=Kellen E, Hemelt M, Broberg K, "et al." |title=Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review. |journal=Am. J. Epidemiol. |volume=165 |issue= 11 |pages= 1221–30 |year= 2007 |pmid= 17404387 |doi= 10.1093/aje/kwm003
*cite journal | author=Sekine I, Minna JD, Nishio K, "et al." |title=A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer. |journal=Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer |volume=1 |issue= 1 |pages= 31–7 |year= 2007 |pmid= 17409824 |doi=

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