RAPGEF2

Rap guanine nucleotide exchange factor (GEF) 2, also known as RAPGEF2, is a human gene.cite web | title = Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9693| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000). [supplied by OMIM] cite web | title = Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9693| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Nagase T, Ishikawa K, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=
*cite journal | author=Ohtsuka T, Hata Y, Ide N, "et al." |title=nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). |journal=Biochem. Biophys. Res. Commun. |volume=265 |issue= 1 |pages= 38–44 |year= 1999 |pmid= 10548487 |doi= 10.1006/bbrc.1999.1619
*cite journal | author=Liao Y, Kariya K, Hu CD, "et al." |title=RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37815–20 |year= 2000 |pmid= 10608844 |doi=
*cite journal | author=de Rooij J, Boenink NM, van Triest M, "et al." |title=PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38125–30 |year= 2000 |pmid= 10608883 |doi=
*cite journal | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200
*cite journal | author=Chikumi H, Fukuhara S, Gutkind JS |title=Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12463–73 |year= 2002 |pmid= 11799111 |doi= 10.1074/jbc.M108504200
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 171–84 |year= 2002 |pmid= 12107413 |doi=
*cite journal | author=Aurandt J, Vikis HG, Gutkind JS, "et al." |title=The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12085–90 |year= 2002 |pmid= 12196628 |doi= 10.1073/pnas.142433199
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Hisata S, Sakisaka T, Baba T, "et al." |title=Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. |journal=J. Cell Biol. |volume=178 |issue= 5 |pages= 843–60 |year= 2007 |pmid= 17724123 |doi= 10.1083/jcb.200610073

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