UMP kinase

In enzymology, an UMP kinase (EC number|2.7.4.22) is an enzyme that catalyzes the chemical reaction

:ATP + UMP $ightleftharpoons$ ADP + UDP

Thus, the two substrates of this enzyme are ATP and UMP, whereas its two products are ADP and UDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:UMP phosphotransferase. Other names in common use include uridylate kinase, UMPK, uridine monophosphate kinase, PyrH, UMP-kinase, and SmbA. This enzyme participates in pyrimidine metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2J4J, PDB link|2J4K, PDB link|2J4L, and PDB link|2VA1.

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