TRNA nucleotidyltransferase

TRNA nucleotidyltransferase

In enzymology, a tRNA nucleotidyltransferase (EC number|2.7.7.56) is an enzyme that catalyzes the chemical reaction

:tRNAn+1 + phosphate ightleftharpoons tRNAn + a nucleoside diphosphate

Thus, the two substrates of this enzyme are tRNA(n+1) and phosphate, whereas its two products are tRNA(n) and nucleoside diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is tRNA:phosphate nucleotidyltransferase. Other names in common use include phosphate-dependent exonuclease, RNase PH, and ribonuclease PH.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1OYP, PDB link|1OYR, PDB link|1OYS, PDB link|1R6L, PDB link|1R6M, PDB link|1UDN, PDB link|1UDO, PDB link|1UDQ, and PDB link|1UDS.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|116412-36-3."

Gene Ontology (GO) codes


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