TRNA cytidylyltransferase

In enzymology, a tRNA cytidylyltransferase (EC number|2.7.7.21) is an enzyme that catalyzes the chemical reaction

:CTP + tRNAn $ightleftharpoons$ diphosphate + tRNAn⁺1Dubious|date=August 2008

Thus, the two substrates of this enzyme are CTP and tRNA(n), whereas its two products are diphosphate and tRNA(n+1).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:tRNA cytidylyltransferase. Other names in common use include tRNA CCA-pyrophosphorylase, tRNA-nucleotidyltransferase, transfer-RNA nucleotidyltransferase, transfer ribonucleic acid nucleotidyl transferase, CTP(ATP):tRNA nucleotidyltransferase, transfer ribonucleate adenylyltransferase, transfer RNA adenylyltransferase, transfer ribonucleate nucleotidyltransferase, ATP (CTP):tRNA nucleotidyltransferase, ribonucleic cytidylic cytidylic adenylic pyrophosphorylase, transfer ribonucleate nucleotidyltransferase, transfer ribonucleic adenylyl (cytidylyl) transferase, transfer ribonucleic-terminal trinucleotide nucleotidyltransferase, transfer ribonucleate cytidylyltransferase, ribonucleic cytidylyltransferase, -C-C-A pyrophosphorylase, ATP(CTP)-tRNA nucleotidyltransferase, tRNA adenylyl(cytidylyl)transferase, ATP(CTP):tRNA nucleotidyltransferase, tRNA adenylyltransferase, and ATP:tRNA adenylyltransferase.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2DR5, PDB link|2DR7, PDB link|2DR8, PDB link|2DR9, PDB link|2DRA, PDB link|2DRB, and PDB link|2DVI.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-32-8."

Gene Ontology (GO) codes