TRNT1

tRNA nucleotidyl transferase, CCA-adding, 1, also known as TRNT1, is a human gene.cite web | title = Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51095| accessdate = ] This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates a binding pocket for an amino acid. [cite journal |author=Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M |title=A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair |journal=Biochimie |volume=90 |issue=5 |pages=762–72 |year=2008 |month=May |pmid=18226598 |doi=10.1016/j.biochi.2007.12.007]

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References

Further reading

PBB_Further_reading
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*cite journal | author=Lai CH, Chou CY, Ch'ang LY, "et al." |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Nagaike T, Suzuki T, Tomari Y, "et al." |title=Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40041–9 |year= 2001 |pmid= 11504732 |doi= 10.1074/jbc.M106202200
*cite journal | author=Reichert AS, Thurlow DL, Mörl M |title=A eubacterial origin for the human tRNA nucleotidyltransferase? |journal=Biol. Chem. |volume=382 |issue= 10 |pages= 1431–8 |year= 2002 |pmid= 11727826 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Augustin MA, Reichert AS, Betat H, "et al." |title=Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. |journal=J. Mol. Biol. |volume=328 |issue= 5 |pages= 985–94 |year= 2003 |pmid= 12729736 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Lizano E, Schuster J, Müller M, "et al." |title=A splice variant of the human CCA-adding enzyme with modified activity. |journal=J. Mol. Biol. |volume=366 |issue= 4 |pages= 1258–65 |year= 2007 |pmid= 17204286 |doi= 10.1016/j.jmb.2006.12.016

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