CLK2

CDC-like kinase 2, also known as CLK2, is a human gene.cite web | title = Entrez Gene: CLK2 CDC-like kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1196| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.cite web | title = Entrez Gene: CLK2 CDC-like kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1196| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hanes J, von der Kammer H, Klaudiny J, Scheit KH |title=Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. |journal=J. Mol. Biol. |volume=244 |issue= 5 |pages= 665–72 |year= 1995 |pmid= 7990150 |doi= 10.1006/jmbi.1994.1763
*cite journal | author=Lee K, Du C, Horn M, Rabinow L |title=Activity and autophosphorylation of LAMMER protein kinases. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27299–303 |year= 1996 |pmid= 8910305 |doi=
*cite journal | author=Winfield SL, Tayebi N, Martin BM, "et al." |title=Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. |journal=Genome Res. |volume=7 |issue= 10 |pages= 1020–6 |year= 1997 |pmid= 9331372 |doi=
*cite journal | author=Duncan PI, Stojdl DF, Marius RM, "et al." |title=The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. |journal=Exp. Cell Res. |volume=241 |issue= 2 |pages= 300–8 |year= 1998 |pmid= 9637771 |doi= 10.1006/excr.1998.4083
*cite journal | author=Tsujikawa M, Kurahashi H, Tanaka T, "et al." |title=Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p. |journal=Am. J. Hum. Genet. |volume=63 |issue= 4 |pages= 1073–7 |year= 1998 |pmid= 9758629 |doi=
*cite journal | author=Nayler O, Schnorrer F, Stamm S, Ullrich A |title=The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34341–8 |year= 1999 |pmid= 9852100 |doi=
*cite journal | author=Talmadge CB, Finkernagel S, Sumegi J, "et al." |title=Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. |journal=Hum. Genet. |volume=103 |issue= 4 |pages= 523–4 |year= 1998 |pmid= 9856501 |doi=
*cite journal | author=Moeslein FM, Myers MP, Landreth GE |title=The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26697–704 |year= 1999 |pmid= 10480872 |doi=
*cite journal | author=Nothwang HG, Kim HG, Aoki J, "et al." |title=Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain. |journal=Hum. Mol. Genet. |volume=10 |issue= 8 |pages= 797–806 |year= 2001 |pmid= 11285245 |doi=
*cite journal | author=Ravichandran LV, Chen H, Li Y, Quon MJ |title=Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. |journal=Mol. Endocrinol. |volume=15 |issue= 10 |pages= 1768–80 |year= 2002 |pmid= 11579209 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jiang N, Bénard CY, Kébir H, "et al." |title=Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21678–84 |year= 2003 |pmid= 12670948 |doi= 10.1074/jbc.M300286200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Collis SJ, Barber LJ, Clark AJ, "et al." |title=HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. |journal=Nat. Cell Biol. |volume=9 |issue= 4 |pages= 391–401 |year= 2007 |pmid= 17384638 |doi= 10.1038/ncb1555

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