Dual-specificity phosphatase

Dual-specificity phosphatase

Dual-specificity phosphatase is a form of phosphatase that can act upon tyrosine or serine/threonine residues.[1]

References

  1. ^ MeSH Dual-Specificity+Phosphatases
v · Intracellular signaling peptides and proteins
MAP
see MAP kinase pathway
Calcium
Intracellular calcium-sensing proteins • Calcineurin • Calcium-calmodulin-dependent protein kinase
G protein

cAMP: Heterotrimeric G protein (Gs/Gi) • Adenylate cyclase • cAMP • 3',5'-cyclic-AMP phosphodiesterase • Protein kinase A

cGMP: Guanylate cyclase • cGMP • 3',5'-cyclic-GMP phosphodiesterase • Protein kinase G

Beta-gamma complex Gβ (GNB1, GNB2, GNB3, GNB4, GNB5) • Gγ (GNGT1, GNGT2, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, BSCL2)

G protein-coupled receptor kinase • AMP-activated protein kinase
ARFs · Rabs · Ras (HRAS, KRAS, NRAS)
Cyclin
Lipid
Phosphoinositide phospholipase C • Phospholipase c gamma
Other protein kinase

Serine/threonine: Casein kinase (1, 2) • eIF-2 kinase (EIF2AK3) • Glycogen synthase kinase (GSK1, GSK2, GSK-3, GSK3A, GSK3B) • IκB kinase (CHUK, IKK2, IKBKG) • Interleukin-1 receptor-associated kinase (IRAK1, IRAK2, IRAK3, IRAK4) • Lim kinase (LIMK1, LIMK2) • p21 activated kinases (PAK1, PAK2, PAK3, PAK4) • Rho-associated protein kinase (ROCK1, ROCK2) • Ribosomal s6 kinase (RPS6KA1)

Tyrosine: ZAP70 • Focal adhesion protein-tyrosine kinase (PTK2, PTK2B) • BTK

both: Dual-specificity kinase
Other phosphoprotein phosphatase

Serine/threonine: Protein phosphatase 2

Tyrosine: protein tyrosine phosphatase: Receptor-like protein tyrosine phosphatase • Sh2 domain-containing protein tyrosine phosphatase

both: Dual-specificity phosphatase
Apoptosis
see apoptosis signaling pathway
GTP-binding protein regulators
Other
Activating transcription factor 6 • Signal transducing adaptor protein • I-kappa B protein • Mucin-4 • Olfactory marker protein • Phosphatidylethanolamine binding protein • EDARADD • PRKCSH
see also deficiencies of intracellular signaling peptides and proteins
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
v · d · eEsterase: protein tyrosine phosphatases (EC 3.1.3.48)
Class I
Classical PTPs

Receptor type PTPs (PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRZ)

Non receptor type PTPs (PTPN1, PTPN2, PTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9, PTPN11, PTPN12, PTPN13, PTPN14, PTPN18, PTPN20, PTPN21, PTPN22, PTPN23
VH1-like or
dual specific
phosphatases
(DSPs)

MAPK phosphatases (MKPs) (DUSP1, DUSP2, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, DUSP10, DUSP16, MK-STYX)

Slingshots (SSH1, SSH2, SSH3)

PRLs (PTP4A1, PTP4A2, PTP4A3)

CDC14s (CDC14A, CDC14B, CDKN3, PTP9Q22)

Atypical DSPs (DUSP3, DUSP11, DUSP12, DUSP13A, DUSP13B, DUSP14, DUSP15, DUSP18, DUSP19, DUSP21, DUSP22, DUSP23, DUSP24, DUSP25, DUSP26, DUSP27, EMP2A, RNGTT, STYX)

Phosphatase and tensin homologs (PTENs) (PTEN, TPIP, TPTE, TNS, TENC1)

Myotubularins (MTM1, MTMR2, MTMR3, MTMR4, MTMR5, MTMR6, MTMR7, MTMR8, MTMR9, MTMR10, MTMR11, MTMR12, MTMR13, MTMR14, MTMR15)
Class II
Class III
Class IV
Eyes absent homolog (EYA1, EYA2, EYA3, EYA4)
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6



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