PTPRB

Protein tyrosine phosphatase, receptor type, B, also known as PTPRB, is a human gene.cite web | title = Entrez Gene: PTPRB protein tyrosine phosphatase, receptor type, B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5787| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation.cite web | title = Entrez Gene: PTPRB protein tyrosine phosphatase, receptor type, B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5787| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Peles E, Schlessinger J, Grumet M |title=Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling. |journal=Trends Biochem. Sci. |volume=23 |issue= 4 |pages= 121–4 |year= 1998 |pmid= 9584610 |doi=
*cite journal | author=Dewang PM, Hsu NM, Peng SZ, Li WR |title=Protein tyrosine phosphatases and their inhibitors. |journal=Curr. Med. Chem. |volume=12 |issue= 1 |pages= 1–22 |year= 2005 |pmid= 15638728 |doi=
*cite journal | author=Ramachandran C, Aebersold R, Tonks NK, Pot DA |title=Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases. |journal=Biochemistry |volume=31 |issue= 17 |pages= 4232–8 |year= 1992 |pmid= 1373652 |doi=
*cite journal | author=Harder KW, Anderson LL, Duncan AM, Jirik FR |title=The gene for receptor-like protein tyrosine phosphatase (PTPRB) is assigned to chromosome 12q15-->q21. |journal=Cytogenet. Cell Genet. |volume=61 |issue= 4 |pages= 269–70 |year= 1993 |pmid= 1486802 |doi=
*cite journal | author=De Vries L, Li RY, Ragab A, "et al." |title=Expression of a truncated protein-tyrosine phosphatase mRNA in human lung. |journal=FEBS Lett. |volume=282 |issue= 2 |pages= 285–8 |year= 1991 |pmid= 1645282 |doi=
*cite journal | author=Kaplan R, Morse B, Huebner K, "et al." |title=Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 18 |pages= 7000–4 |year= 1990 |pmid= 2169617 |doi=
*cite journal | author=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241–52 |year= 1990 |pmid= 2170109 |doi=
*cite journal | author=Gaits F, Li RY, Ragab A, "et al." |title=Increase in receptor-like protein tyrosine phosphatase activity and expression level on density-dependent growth arrest of endothelial cells. |journal=Biochem. J. |volume=311 ( Pt 1) |issue= |pages= 97–103 |year= 1995 |pmid= 7575486 |doi=
*cite journal | author=Peles E, Nativ M, Campbell PL, "et al." |title=The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. |journal=Cell |volume=82 |issue= 2 |pages= 251–60 |year= 1995 |pmid= 7628014 |doi=
*cite journal | author=Sakurai T, Lustig M, Nativ M, "et al." |title=Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 907–18 |year= 1997 |pmid= 9049255 |doi=
*cite journal | author=Peles E, Nativ M, Lustig M, "et al." |title=Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. |journal=EMBO J. |volume=16 |issue= 5 |pages= 978–88 |year= 1997 |pmid= 9118959 |doi= 10.1093/emboj/16.5.978
*cite journal | author=Feito MJ, Bragardo M, Buonfiglio D, "et al." |title=gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules. |journal=Int. Immunol. |volume=9 |issue= 8 |pages= 1141–7 |year= 1997 |pmid= 9263011 |doi=
*cite journal | author=Fachinger G, Deutsch U, Risau W |title=Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. |journal=Oncogene |volume=18 |issue= 43 |pages= 5948–53 |year= 1999 |pmid= 10557082 |doi= 10.1038/sj.onc.1202992
*cite journal | author=Meng K, Rodriguez-Peña A, Dimitrov T, "et al." |title=Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2603–8 |year= 2000 |pmid= 10706604 |doi= 10.1073/pnas.020487997
*cite journal | author=Ratcliffe CF, Qu Y, McCormick KA, "et al." |title=A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. |journal=Nat. Neurosci. |volume=3 |issue= 5 |pages= 437–44 |year= 2000 |pmid= 10769382 |doi= 10.1038/74805
*cite journal | author=Adamsky K, Schilling J, Garwood J, "et al." |title=Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. |journal=Oncogene |volume=20 |issue= 5 |pages= 609–18 |year= 2001 |pmid= 11313993 |doi= 10.1038/sj.onc.1204119
*cite journal | author=Cheburkin IuV, Kniazeva TG, Peter S, "et al." |title= [Molecular portrait of human kidney carcinomas: the gene expression profiling of protein-tyrosine kinases and tyrosine phosphatases which controlled regulatory signals in the cells] |journal=Mol. Biol. (Mosk.) |volume=36 |issue= 3 |pages= 480–90 |year= 2002 |pmid= 12068634 |doi=
*cite journal | author=Nawroth R, Poell G, Ranft A, "et al." |title=VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4885–95 |year= 2002 |pmid= 12234928 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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