PTPRN

Protein tyrosine phosphatase, receptor type, N, also known as PTPRN, is a human gene.cite web | title = Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5798| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.cite web | title = Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5798| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lan MS, Lu J, Goto Y, Notkins AL |title=Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. |journal=DNA Cell Biol. |volume=13 |issue= 5 |pages= 505–14 |year= 1994 |pmid= 8024693 |doi=
*cite journal | author=Rabin DU, Pleasic SM, Shapiro JA, "et al." |title=Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. |journal=J. Immunol. |volume=152 |issue= 6 |pages= 3183–8 |year= 1994 |pmid= 8144912 |doi=
*cite journal | author=Solimena M, Dirkx R, Hermel JM, "et al." |title=ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. |journal=EMBO J. |volume=15 |issue= 9 |pages= 2102–14 |year= 1996 |pmid= 8641276 |doi=
*cite journal | author=van den Maagdenberg AM, Olde Weghuis D, Rijss J, "et al." |title=Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 145–8 |year= 1996 |pmid= 8646884 |doi=
*cite journal | author=Cui L, Yu WP, DeAizpurua HJ, "et al." |title=Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24817–23 |year= 1996 |pmid= 8798755 |doi=
*cite journal | author=Xie J, Zhang B, Lan MS, Notkins AL |title=Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN). |journal=Genomics |volume=54 |issue= 2 |pages= 338–43 |year= 1999 |pmid= 9828138 |doi= 10.1006/geno.1998.5583
*cite journal | author=Ort T, Maksimova E, Dirkx R, "et al." |title=The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. |journal=Eur. J. Cell Biol. |volume=79 |issue= 9 |pages= 621–30 |year= 2001 |pmid= 11043403 |doi=
*cite journal | author=Park YS, Kawasaki E, Kelemen K, "et al." |title=Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes. |journal=Diabetologia |volume=43 |issue= 10 |pages= 1293–301 |year= 2001 |pmid= 11079748 |doi=
*cite journal | author=Berghs S, Aggujaro D, Dirkx R, "et al." |title=betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system. |journal=J. Cell Biol. |volume=151 |issue= 5 |pages= 985–1002 |year= 2001 |pmid= 11086001 |doi=
*cite journal | author=Diez J, Park Y, Zeller M, "et al." |title=Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. |journal=Diabetes |volume=50 |issue= 4 |pages= 895–900 |year= 2001 |pmid= 11289059 |doi=
*cite journal | author=Ort T, Voronov S, Guo J, "et al." |title=Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4013–23 |year= 2001 |pmid= 11483505 |doi= 10.1093/emboj/20.15.4013
*cite journal | author=Mikulecký M, Michalková D |title=Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children. |journal=Biomed. Pharmacother. |volume=55 Suppl 1 |issue= |pages= 106s-109s |year= 2002 |pmid= 11774856 |doi=
*cite journal | author=Miao D, Yu L, Tiberti C, "et al." |title=ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies. |journal=J. Autoimmun. |volume=18 |issue= 2 |pages= 191–6 |year= 2002 |pmid= 11908951 |doi= 10.1006/jaut.2001.0577
*cite journal | author=Kawasaki E, Yamaguchi H, Hattori H, "et al." |title=Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay. |journal=Ann. N. Y. Acad. Sci. |volume=958 |issue= |pages= 241–6 |year= 2002 |pmid= 12021115 |doi=
*cite journal | author=Sanjeevi CB, Das AK, Shtauvere-Brameus A |title=BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India. |journal=Ann. N. Y. Acad. Sci. |volume=958 |issue= |pages= 293–6 |year= 2002 |pmid= 12021127 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bearzatto M, Lampasona V, Belloni C, Bonifacio E |title=Fine mapping of diabetes-associated IA-2 specific autoantibodies. |journal=J. Autoimmun. |volume=21 |issue= 4 |pages= 377–82 |year= 2004 |pmid= 14624760 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Trajkovski M, Mziaut H, Altkrüger A, "et al." |title=Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells. |journal=J. Cell Biol. |volume=167 |issue= 6 |pages= 1063-74 |year= 2005 |pmid= 15596545 |doi= 10.1083/jcb.200408172
*cite journal | author=Ota T, Takamura T, Nagai Y, "et al." |title=Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody. |journal=Diabetes Res. Clin. Pract. |volume=67 |issue= 1 |pages= 63–9 |year= 2005 |pmid= 15620435 |doi= 10.1016/j.diabres.2004.05.004

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